node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BET1L | UBC | ENSP00000372210 | ENSP00000344818 | blocked early in transport 1 homolog (S. cerevisiae)-like; Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity) | ubiquitin C | 0.731 |
FARSA | UBC | ENSP00000320309 | ENSP00000344818 | phenylalanyl-tRNA synthetase, alpha subunit | ubiquitin C | 0.959 |
GORAB | MDM2 | ENSP00000356737 | ENSP00000417281 | golgin, RAB6-interacting | Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) | 0.677 |
GORAB | RCHY1 | ENSP00000356737 | ENSP00000321239 | golgin, RAB6-interacting | ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase; Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity | 0.955 |
GORAB | SCYL1 | ENSP00000356737 | ENSP00000270176 | golgin, RAB6-interacting | SCY1-like 1 (S. cerevisiae); Regulates COPI-mediated retrograde traffic. Has no detectable kinase activity in vitro | 0.945 |
GORAB | UBC | ENSP00000356737 | ENSP00000344818 | golgin, RAB6-interacting | ubiquitin C | 0.576 |
HSD17B7 | UBC | ENSP00000254521 | ENSP00000344818 | hydroxysteroid (17-beta) dehydrogenase 7; Responsible for the reduction of the keto group on the C-3 of sterols | ubiquitin C | 0.939 |
MDM2 | GORAB | ENSP00000417281 | ENSP00000356737 | Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) | golgin, RAB6-interacting | 0.677 |
MDM2 | RCHY1 | ENSP00000417281 | ENSP00000321239 | Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) | ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase; Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity | 0.912 |
MDM2 | UBC | ENSP00000417281 | ENSP00000344818 | Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) | ubiquitin C | 0.999 |
NEDD4L | UBC | ENSP00000383199 | ENSP00000344818 | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | ubiquitin C | 0.999 |
PTAFR | UBC | ENSP00000301974 | ENSP00000344818 | platelet-activating factor receptor; Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol- calcium second messenger system | ubiquitin C | 0.581 |
RCHY1 | GORAB | ENSP00000321239 | ENSP00000356737 | ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase; Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity | golgin, RAB6-interacting | 0.955 |
RCHY1 | MDM2 | ENSP00000321239 | ENSP00000417281 | ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase; Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity | Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) | 0.912 |
RCHY1 | SCYL1 | ENSP00000321239 | ENSP00000270176 | ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase; Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity | SCY1-like 1 (S. cerevisiae); Regulates COPI-mediated retrograde traffic. Has no detectable kinase activity in vitro | 0.748 |
RCHY1 | UBC | ENSP00000321239 | ENSP00000344818 | ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase; Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity | ubiquitin C | 0.997 |
SCYL1 | GORAB | ENSP00000270176 | ENSP00000356737 | SCY1-like 1 (S. cerevisiae); Regulates COPI-mediated retrograde traffic. Has no detectable kinase activity in vitro | golgin, RAB6-interacting | 0.945 |
SCYL1 | RCHY1 | ENSP00000270176 | ENSP00000321239 | SCY1-like 1 (S. cerevisiae); Regulates COPI-mediated retrograde traffic. Has no detectable kinase activity in vitro | ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase; Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity | 0.748 |
SCYL1 | UBC | ENSP00000270176 | ENSP00000344818 | SCY1-like 1 (S. cerevisiae); Regulates COPI-mediated retrograde traffic. Has no detectable kinase activity in vitro | ubiquitin C | 0.581 |
UBC | BET1L | ENSP00000344818 | ENSP00000372210 | ubiquitin C | blocked early in transport 1 homolog (S. cerevisiae)-like; Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity) | 0.731 |