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CFP | complement factor properdin; A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes (469 aa) | |||
ADAMTS8 | ADAM metallopeptidase with thrombospondin type 1 motif, 8; Has anti-angiogenic properties (889 aa) | |||
THSD1 | thrombospondin, type I, domain containing 1 (852 aa) | |||
THBS1 | thrombospondin 1; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties (1170 aa) | |||
ADAMTSL4 | ADAMTS-like 4; Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis (1074 aa) | |||
THSD7B | thrombospondin, type I, domain containing 7B (1609 aa) | |||
ADAMTS16 | ADAM metallopeptidase with thrombospondin type 1 motif, 16 (1224 aa) | |||
ADAMTS19 | ADAM metallopeptidase with thrombospondin type 1 motif, 19 (1207 aa) | |||
ADAMTS18 | ADAM metallopeptidase with thrombospondin type 1 motif, 18 (1221 aa) | |||
ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture (967 aa) | |||
ADAMTS5 | ADAM metallopeptidase with thrombospondin type 1 motif, 5; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period (930 aa) | |||
ADAMTS3 | ADAM metallopeptidase with thrombospondin type 1 motif, 3; Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens (1205 aa) | |||
ADAMTSL3 | ADAMTS-like 3 (1691 aa) | |||
SPON2 | spondin 2, extracellular matrix protein; Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern- recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS) (331 aa) | |||
SBSPON | somatomedin B and thrombospondin, type 1 domain containing (264 aa) | |||
ADAMTS15 | ADAM metallopeptidase with thrombospondin type 1 motif, 15 (950 aa) | |||
SEMA5B | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B; May act as positive axonal guidance cues (By similarity) (1151 aa) | |||
THBS2 | thrombospondin 2; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties (1172 aa) | |||
ADAMTS4 | ADAM metallopeptidase with thrombospondin type 1 motif, 4; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the ’392-Glu-|-Ala-393’ site (837 aa) | |||
ADAMTS14 | ADAM metallopeptidase with thrombospondin type 1 motif, 14; Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity (1226 aa) | |||
ADAMTSL1 | ADAMTS-like 1 (1762 aa) | |||
ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 (1117 aa) | |||
ADAMTS7 | ADAM metallopeptidase with thrombospondin type 1 motif, 7; Metalloprotease that may play a role in the degradation of COMP (1686 aa) | |||
ADAMTS20 | ADAM metallopeptidase with thrombospondin type 1 motif, 20; May play a role in tissue-remodeling process occurring in both normal and pathological conditions (1910 aa) | |||
THSD7A | thrombospondin, type I, domain containing 7A; The soluble form promotes endothelial cell migration and filopodia formationduring angiogenesis via a FAK-dependent mechanism (1657 aa) | |||
ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9; Cleaves the large aggregating proteoglycans, aggrecan and versican (1935 aa) |