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ADAMTS14 ADAMTS14 SBSPON SBSPON SPON2 SPON2 ADAMTSL4 ADAMTSL4 ADAMTS7 ADAMTS7 ADAMTSL1 ADAMTSL1 ADAMTS15 ADAMTS15 ADAMTS19 ADAMTS19 ADAMTS5 ADAMTS5 CFP CFP THSD7B THSD7B ADAMTS8 ADAMTS8 THBS1 THBS1 ADAMTS16 ADAMTS16 THSD1 THSD1 ADAMTS1 ADAMTS1 ADAMTS4 ADAMTS4 THBS2 THBS2 ADAMTS3 ADAMTS3 ADAMTS18 ADAMTS18 THSD7A THSD7A ADAMTSL3 ADAMTSL3 SEMA5B SEMA5B ADAMTS20 ADAMTS20 ADAMTS6 ADAMTS6 ADAMTS9 ADAMTS9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
CFPcomplement factor properdin; A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes (469 aa)
ADAMTS8ADAM metallopeptidase with thrombospondin type 1 motif, 8; Has anti-angiogenic properties (889 aa)
THSD1thrombospondin, type I, domain containing 1 (852 aa)
THBS1thrombospondin 1; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties (1170 aa)
ADAMTSL4ADAMTS-like 4; Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis (1074 aa)
THSD7Bthrombospondin, type I, domain containing 7B (1609 aa)
ADAMTS16ADAM metallopeptidase with thrombospondin type 1 motif, 16 (1224 aa)
ADAMTS19ADAM metallopeptidase with thrombospondin type 1 motif, 19 (1207 aa)
ADAMTS18ADAM metallopeptidase with thrombospondin type 1 motif, 18 (1221 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif, 1; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture (967 aa)
ADAMTS5ADAM metallopeptidase with thrombospondin type 1 motif, 5; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period (930 aa)
ADAMTS3ADAM metallopeptidase with thrombospondin type 1 motif, 3; Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens (1205 aa)
ADAMTSL3ADAMTS-like 3 (1691 aa)
SPON2spondin 2, extracellular matrix protein; Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern- recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS) (331 aa)
SBSPONsomatomedin B and thrombospondin, type 1 domain containing (264 aa)
ADAMTS15ADAM metallopeptidase with thrombospondin type 1 motif, 15 (950 aa)
SEMA5Bsema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B; May act as positive axonal guidance cues (By similarity) (1151 aa)
THBS2thrombospondin 2; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties (1172 aa)
ADAMTS4ADAM metallopeptidase with thrombospondin type 1 motif, 4; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the ’392-Glu-|-Ala-393’ site (837 aa)
ADAMTS14ADAM metallopeptidase with thrombospondin type 1 motif, 14; Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity (1226 aa)
ADAMTSL1ADAMTS-like 1 (1762 aa)
ADAMTS6ADAM metallopeptidase with thrombospondin type 1 motif, 6 (1117 aa)
ADAMTS7ADAM metallopeptidase with thrombospondin type 1 motif, 7; Metalloprotease that may play a role in the degradation of COMP (1686 aa)
ADAMTS20ADAM metallopeptidase with thrombospondin type 1 motif, 20; May play a role in tissue-remodeling process occurring in both normal and pathological conditions (1910 aa)
THSD7Athrombospondin, type I, domain containing 7A; The soluble form promotes endothelial cell migration and filopodia formationduring angiogenesis via a FAK-dependent mechanism (1657 aa)
ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif, 9; Cleaves the large aggregating proteoglycans, aggrecan and versican (1935 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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