Rho GTPase activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42

Rho GDP dissociation inhibitor (GDI) alpha; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1 (By similarity)

Rho GTPase activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42

Rho GDP dissociation inhibitor (GDI) beta; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them

Rho GTPase activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42

Rho GDP dissociation inhibitor (GDI) gamma; Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post- translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP

Rho GTPase activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42

Rho/Rac guanine nucleotide exchange factor (GEF) 18; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell [...]

Rho GTPase activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42

Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; Acts as a RAC1 guanine nucleotide exchange factor (GEF)

Rho GTPase activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42

FYVE, RhoGEF and PH domain containing 2; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5- bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4- monophosphate and phosphatidylinositol 3-monophosphate (By similarity)

Rho GTPase activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42

FYVE, RhoGEF and PH domain containing 4; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity)

Rho GTPase activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42

GDP dissociation inhibitor 2; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them

Rho GTPase activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42

kalirin, RhoGEF kinase; Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity

Rho GTPase activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42

MCF.2 cell line derived transforming sequence

Rho GTPase activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

Rho GTPase activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42

ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase

Rho GTPase activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42

Ras protein-specific guanine nucleotide-releasing factor 2; Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation

Rho GTPase activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42

ras homolog family member C; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells

Rho GTPase activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42

ras homolog family member F (in filopodia); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin- based morphology

Rho GTPase activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42

ras homolog family member G; Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry

Rho GTPase activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42

ras homolog family member Q; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia

Rho GTPase activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42

ras homolog family member T1; Mitochondrial GTPase involved in mitochondrial trafficking (By similarity)

Rho GTPase activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42

ras homolog family member V; Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway (By similarity)

Rho GTPase activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42

son of sevenless homolog 1 (Drosophila); Promotes the exchange of Ras-bound GDP by GTP. Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity)