node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGEF7 | CD244 | ENSP00000364893 | ENSP00000357012 | Rho guanine nucleotide exchange factor (GEF) 7 | CD244 molecule, natural killer cell receptor 2B4; Modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family | 0.570 |
ARHGEF7 | FYN | ENSP00000364893 | ENSP00000346671 | Rho guanine nucleotide exchange factor (GEF) 7 | FYN oncogene related to SRC, FGR, YES; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motilit [...] | 0.951 |
ARHGEF7 | SH2D1A | ENSP00000364893 | ENSP00000360181 | Rho guanine nucleotide exchange factor (GEF) 7 | SH2 domain containing 1A; Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3 | 0.577 |
CD244 | ARHGEF7 | ENSP00000357012 | ENSP00000364893 | CD244 molecule, natural killer cell receptor 2B4; Modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family | Rho guanine nucleotide exchange factor (GEF) 7 | 0.570 |
CD244 | CD247 | ENSP00000357012 | ENSP00000354782 | CD244 molecule, natural killer cell receptor 2B4; Modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | 0.663 |
CD244 | CD48 | ENSP00000357012 | ENSP00000357025 | CD244 molecule, natural killer cell receptor 2B4; Modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family | CD48 molecule; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation | 0.993 |
CD244 | FYN | ENSP00000357012 | ENSP00000346671 | CD244 molecule, natural killer cell receptor 2B4; Modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family | FYN oncogene related to SRC, FGR, YES; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motilit [...] | 0.928 |
CD244 | LAT | ENSP00000357012 | ENSP00000378845 | CD244 molecule, natural killer cell receptor 2B4; Modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family | linker for activation of T cells; Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization [...] | 0.923 |
CD244 | SH2D1A | ENSP00000357012 | ENSP00000360181 | CD244 molecule, natural killer cell receptor 2B4; Modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family | SH2 domain containing 1A; Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3 | 0.992 |
CD244 | SH2D1B | ENSP00000357012 | ENSP00000356906 | CD244 molecule, natural killer cell receptor 2B4; Modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family | SH2 domain containing 1B; Plays a role in controlling signal transduction through at least four receptors, CD84, SLAMF1, LY9 and CD244, expressed on the surface of professional antigen-presenting cells | 0.954 |
CD244 | SH3BP2 | ENSP00000357012 | ENSP00000422168 | CD244 molecule, natural killer cell receptor 2B4; Modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family | SH3-domain binding protein 2; Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism | 0.587 |
CD247 | CD244 | ENSP00000354782 | ENSP00000357012 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | CD244 molecule, natural killer cell receptor 2B4; Modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family | 0.663 |
CD247 | CD48 | ENSP00000354782 | ENSP00000357025 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | CD48 molecule; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation | 0.627 |
CD247 | FYN | ENSP00000354782 | ENSP00000346671 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | FYN oncogene related to SRC, FGR, YES; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motilit [...] | 0.975 |
CD247 | LAT | ENSP00000354782 | ENSP00000378845 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | linker for activation of T cells; Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization [...] | 0.974 |
CD247 | SH3BP2 | ENSP00000354782 | ENSP00000422168 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | SH3-domain binding protein 2; Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism | 0.901 |
CD48 | CD244 | ENSP00000357025 | ENSP00000357012 | CD48 molecule; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation | CD244 molecule, natural killer cell receptor 2B4; Modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family | 0.993 |
CD48 | CD247 | ENSP00000357025 | ENSP00000354782 | CD48 molecule; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | 0.627 |
CD48 | FYN | ENSP00000357025 | ENSP00000346671 | CD48 molecule; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation | FYN oncogene related to SRC, FGR, YES; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motilit [...] | 0.656 |
CD48 | SH2D1A | ENSP00000357025 | ENSP00000360181 | CD48 molecule; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation | SH2 domain containing 1A; Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3 | 0.610 |