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ABCD1 | ATP-binding cassette, sub-family D (ALD), member 1; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity (745 aa) | |||
PEX11G | peroxisomal biogenesis factor 11 gamma (241 aa) | |||
PEX12 | peroxisomal biogenesis factor 12; Required for protein import into peroxisomes (359 aa) | |||
PEX16 | peroxisomal biogenesis factor 16; Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3 (346 aa) | |||
DSTN | destrin (actin depolymerizing factor); Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH- independent manner (165 aa) | |||
HSPB1 | heat shock 27kDa protein 1 (205 aa) | |||
PEX1 | peroxisomal biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes (1283 aa) | |||
NUBP2 | nucleotide binding protein 2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (By similarity) (271 aa) | |||
PEX10 | peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes (346 aa) | |||
PEX13 | peroxisomal biogenesis factor 13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins (403 aa) | |||
PEX11A | peroxisomal biogenesis factor 11 alpha; May be involved in peroxisomal proliferation and may regulate peroxisomes division. May mediate binding of coatomer proteins to the peroxisomal membrane (247 aa) | |||
PEX6 | peroxisomal biogenesis factor 6; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes (980 aa) | |||
NUDCD2 | NudC domain containing 2; May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone (157 aa) | |||
PMP22 | peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system (160 aa) | |||
ABCD2 | ATP-binding cassette, sub-family D (ALD), member 2; Probable transporter (740 aa) | |||
PXMP2 | peroxisomal membrane protein 2, 22kDa; Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane (195 aa) | |||
UBC | ubiquitin C (685 aa) | |||
PEX14 | peroxisomal biogenesis factor 14; Component of the peroxisomal translocation machinery with PEX13 and PEX17. Interacts with both the PTS1 and PTS2 receptors. Binds directly to PEX17 (377 aa) | |||
PEX2 | peroxisomal biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes (305 aa) | |||
PEX3 | peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes (373 aa) | |||
PEX19 | peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 (299 aa) | |||
PEX11B | peroxisomal biogenesis factor 11 beta (259 aa) | |||
ABCD3 | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity (659 aa) | |||
CCT4 | chaperonin containing TCP1, subunit 4 (delta); Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin (539 aa) | |||
PXMP4 | peroxisomal membrane protein 4, 24kDa (212 aa) | |||
SLC25A17 | solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17; Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extend for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3’,5’- diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter- exchange mechanism. Inhibited by pyridoxal 5’-phosphate and ba [...] (307 aa) |