node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATF4 | BGLAP | ENSP00000336790 | ENSP00000357255 | activating transcription factor 4 (tax-responsive enhancer element B67); Transcriptional activator. Binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert wit [...] | bone gamma-carboxyglutamate (gla) protein; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium | 0.986 |
ATF4 | RUNX2 | ENSP00000336790 | ENSP00000360493 | activating transcription factor 4 (tax-responsive enhancer element B67); Transcriptional activator. Binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert wit [...] | runt-related transcription factor 2; Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5’- PYGPYGGT-3’, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation- synergizes with SPEN/MINT to enhance FGFR2-media [...] | 0.909 |
ATF4 | TBP | ENSP00000336790 | ENSP00000230354 | activating transcription factor 4 (tax-responsive enhancer element B67); Transcriptional activator. Binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert wit [...] | TATA box binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre- initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 wi [...] | 0.930 |
BGLAP | ATF4 | ENSP00000357255 | ENSP00000336790 | bone gamma-carboxyglutamate (gla) protein; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium | activating transcription factor 4 (tax-responsive enhancer element B67); Transcriptional activator. Binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert wit [...] | 0.986 |
BGLAP | CTSB | ENSP00000357255 | ENSP00000342070 | bone gamma-carboxyglutamate (gla) protein; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium | cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | 0.596 |
BGLAP | CTSD | ENSP00000357255 | ENSP00000236671 | bone gamma-carboxyglutamate (gla) protein; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium | cathepsin D; Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease | 0.595 |
BGLAP | CTSH | ENSP00000357255 | ENSP00000220166 | bone gamma-carboxyglutamate (gla) protein; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium | cathepsin H; Important for the overall degradation of proteins in lysosomes | 0.569 |
BGLAP | CTSS | ENSP00000357255 | ENSP00000357981 | bone gamma-carboxyglutamate (gla) protein; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium | cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N | 0.614 |
BGLAP | GGCX | ENSP00000357255 | ENSP00000233838 | bone gamma-carboxyglutamate (gla) protein; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium | gamma-glutamyl carboxylase; Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide | 0.827 |
BGLAP | HES1 | ENSP00000357255 | ENSP00000232424 | bone gamma-carboxyglutamate (gla) protein; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium | hairy and enhancer of split 1, (Drosophila); Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs- 5’-CACNAG-3’ with high affinity and on E-box motifs- 5’-CANNTG-3’ with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage | 0.906 |
BGLAP | RB1 | ENSP00000357255 | ENSP00000267163 | bone gamma-carboxyglutamate (gla) protein; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium | retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV [...] | 0.916 |
BGLAP | RUNX2 | ENSP00000357255 | ENSP00000360493 | bone gamma-carboxyglutamate (gla) protein; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium | runt-related transcription factor 2; Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5’- PYGPYGGT-3’, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation- synergizes with SPEN/MINT to enhance FGFR2-media [...] | 0.988 |
BGLAP | TBP | ENSP00000357255 | ENSP00000230354 | bone gamma-carboxyglutamate (gla) protein; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium | TATA box binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre- initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 wi [...] | 0.906 |
CBX5 | RB1 | ENSP00000209875 | ENSP00000267163 | chromobox homolog 5; Component of heterochromatin that recognizes and binds histone H3 tails methylated at ’Lys-9’ (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when ’Tyr-41’ of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins | retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV [...] | 0.831 |
CBX5 | TBP | ENSP00000209875 | ENSP00000230354 | chromobox homolog 5; Component of heterochromatin that recognizes and binds histone H3 tails methylated at ’Lys-9’ (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when ’Tyr-41’ of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins | TATA box binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre- initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 wi [...] | 0.631 |
CTSB | BGLAP | ENSP00000342070 | ENSP00000357255 | cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | bone gamma-carboxyglutamate (gla) protein; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium | 0.596 |
CTSB | CTSD | ENSP00000342070 | ENSP00000236671 | cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | cathepsin D; Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease | 0.960 |
CTSD | BGLAP | ENSP00000236671 | ENSP00000357255 | cathepsin D; Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease | bone gamma-carboxyglutamate (gla) protein; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium | 0.595 |
CTSD | CTSB | ENSP00000236671 | ENSP00000342070 | cathepsin D; Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease | cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | 0.960 |
CTSD | CTSH | ENSP00000236671 | ENSP00000220166 | cathepsin D; Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease | cathepsin H; Important for the overall degradation of proteins in lysosomes | 0.698 |