Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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 | KCND1 | potassium voltage-gated channel, Shal-related subfamily, member 1; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits (647 aa) | ||
 | KCNA7 | potassium voltage-gated channel, shaker-related subfamily, member 7; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (By similarity) (456 aa) | ||
 | KCNA5 | potassium voltage-gated channel, shaker-related subfamily, member 5; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inacti [...] (613 aa) | ||
 | KCNC1 | potassium voltage-gated channel, Shaw-related subfamily, member 1; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (585 aa) | ||
 | KCNA6 | potassium voltage-gated channel, shaker-related subfamily, member 6; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (529 aa) | ||
 | KCNF1 | potassium voltage-gated channel, subfamily F, member 1; Putative voltage-gated potassium channel (494 aa) | ||
 | KCNAB3 | potassium voltage-gated channel, shaker-related subfamily, beta member 3; Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5 (404 aa) | ||
 | SCN1A | sodium channel, voltage-gated, type I, alpha subunit; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (2009 aa) | ||
 | KCNG3 | potassium voltage-gated channel, subfamily G, member 3; Potassium channel subunit. Modulates channel activity (436 aa) | ||
 | KCNS3 | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3; Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity) (491 aa) | ||
 | CAMK2G | calcium/calmodulin-dependent protein kinase II gamma (556 aa) | ||
 | CAMK2D | calcium/calmodulin-dependent protein kinase II delta; Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart f [...] (499 aa) | ||
 | CAV3 | caveolin 3; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (151 aa) | ||
 | KCNQ2 | potassium voltage-gated channel, KQT-like subfamily, member 2 (872 aa) | ||
 | KCNK5 | potassium channel, subfamily K, member 5; pH-dependent, voltage insensitive, outwardly rectifying potassium channel. Outward rectification is lost at high external K(+) concentrations (499 aa) | ||
 | HCN3 | hyperpolarization activated cyclic nucleotide-gated potassium channel 3; Putative hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions (By similarity) (774 aa) | ||
 | KCNG1 | potassium voltage-gated channel, subfamily G, member 1; Probable potassium channel subunit. May need to associate with another protein to form a functional channel. May modulate channel activity (513 aa) | ||
 | KCNAB2 | potassium voltage-gated channel, shaker-related subfamily, beta member 2 (415 aa) | ||
 | CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) (921 aa) | ||
 | KCNV2 | potassium channel, subfamily V, member 2; Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values (545 aa) | ||
 | CAMK2B | calcium/calmodulin-dependent protein kinase II beta (666 aa) | ||
 | CAMK2A | calcium/calmodulin-dependent protein kinase II alpha; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity) (489 aa) | ||
 | KCNK2 | potassium channel, subfamily K, member 2 (426 aa) | ||
 | KCNAB1 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 (419 aa) | ||
 | PEX5L | peroxisomal biogenesis factor 5-like; Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence (By similarity) (626 aa) | ||
 | KCNC2 | potassium voltage-gated channel, Shaw-related subfamily, member 2; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channel properties are modulated by subunit assembly (By similarity) (638 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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