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ARL13A ARL13A ARL2 ARL2 TBCA TBCA TBCD TBCD TBCE TBCE KIF1A KIF1A UBC UBC TUBE1 TUBE1 TUBA3D TUBA3D TUBA1A TUBA1A TUBA8 TUBA8 TUBGCP2 TUBGCP2 MAPRE2 MAPRE2 TUBAL3 TUBAL3 MAPRE3 MAPRE3 KIFC2 KIFC2 TUBGCP3 TUBGCP3 MAPRE1 MAPRE1 MAD2L1 MAD2L1 CKAP5 CKAP5 BUB3 BUB3 TUBGCP6 TUBGCP6 KIFC3 KIFC3 BUB1B BUB1B KIFC1 KIFC1 KIF25 KIF25
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
MAPRE3microtubule-associated protein, RP/EB family, member 3; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity) (281 aa)
ARL2ADP-ribosylation factor-like 2; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of T [...] (184 aa)
TUBGCP6tubulin, gamma complex associated protein 6; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome (1819 aa)
TUBGCP2tubulin, gamma complex associated protein 2; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome (902 aa)
TUBGCP3tubulin, gamma complex associated protein 3; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome (907 aa)
BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast) (1050 aa)
MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast); Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore- spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate (205 aa)
MAPRE2microtubule-associated protein, RP/EB family, member 2; May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity) (327 aa)
TUBA1Atubulin, alpha 1a; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity) (451 aa)
KIFC2kinesin family member C2; May play a role in microtubule-dependent retrograde axonal transport. May function as the motor for the transport of multivesicular body (MVB)-like organelles in dendrites (By similarity) (838 aa)
KIF1Akinesin family member 1A (1690 aa)
TUBA3Dtubulin, alpha 3d; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity) (450 aa)
TUBA8tubulin, alpha 8; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity) (449 aa)
UBCubiquitin C (685 aa)
KIF25kinesin family member 25; Negative regulator of amino acid starvation-induced autophagy (384 aa)
TBCDtubulin folding cofactor D (1192 aa)
TBCEtubulin folding cofactor E; Tubulin-folding protein; involved in the second step of the tubulin folding pathway. Seems to be implicated in the maintenance of the neuronal microtubule network. Involved in regulation of tubulin heterodimer dissociation (527 aa)
TUBE1tubulin, epsilon 1 (475 aa)
BUB3budding uninhibited by benzimidazoles 3 homolog (yeast); Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylatin [...] (328 aa)
MAPRE1microtubule-associated protein, RP/EB family, member 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (268 aa)
KIFC3kinesin family member C3; Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity). Required for zonula adherens maintenance (833 aa)
TBCAtubulin folding cofactor A; Tubulin-folding protein; involved in the early step of the tubulin folding pathway (108 aa)
TUBAL3tubulin, alpha-like 3 (446 aa)
KIFC1kinesin family member C1 (673 aa)
ARL13AADP-ribosylation factor-like 13A (256 aa)
CKAP5cytoskeleton associated protein 5; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles (2032 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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