node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CSTA | EVPL | ENSP00000264474 | ENSP00000301607 | cystatin A (stefin A); This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis | envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments | 0.740 |
CSTA | IVL | ENSP00000264474 | ENSP00000357753 | cystatin A (stefin A); This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis | involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia (By similarity) | 0.763 |
CSTA | KRT1 | ENSP00000264474 | ENSP00000252244 | cystatin A (stefin A); This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis | keratin 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). In complex with C1QBP is a high affinty receptor for kininogen-1/HMWK | 0.759 |
CSTA | LOR | ENSP00000264474 | ENSP00000357731 | cystatin A (stefin A); This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis | loricrin; Major keratinocyte cell envelope protein | 0.757 |
CSTA | PI3 | ENSP00000264474 | ENSP00000243924 | cystatin A (stefin A); This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis | peptidase inhibitor 3, skin-derived; Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis | 0.669 |
EVPL | CSTA | ENSP00000301607 | ENSP00000264474 | envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments | cystatin A (stefin A); This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis | 0.740 |
EVPL | IVL | ENSP00000301607 | ENSP00000357753 | envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments | involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia (By similarity) | 0.852 |
EVPL | KRT1 | ENSP00000301607 | ENSP00000252244 | envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments | keratin 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). In complex with C1QBP is a high affinty receptor for kininogen-1/HMWK | 0.678 |
EVPL | LOR | ENSP00000301607 | ENSP00000357731 | envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments | loricrin; Major keratinocyte cell envelope protein | 0.827 |
EVPL | PI3 | ENSP00000301607 | ENSP00000243924 | envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments | peptidase inhibitor 3, skin-derived; Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis | 0.628 |
EVPL | SPRR3 | ENSP00000301607 | ENSP00000295367 | envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments | small proline-rich protein 3 | 0.598 |
IVL | CSTA | ENSP00000357753 | ENSP00000264474 | involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia (By similarity) | cystatin A (stefin A); This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis | 0.763 |
IVL | EVPL | ENSP00000357753 | ENSP00000301607 | involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia (By similarity) | envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments | 0.852 |
IVL | KRT1 | ENSP00000357753 | ENSP00000252244 | involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia (By similarity) | keratin 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). In complex with C1QBP is a high affinty receptor for kininogen-1/HMWK | 0.908 |
IVL | LOR | ENSP00000357753 | ENSP00000357731 | involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia (By similarity) | loricrin; Major keratinocyte cell envelope protein | 0.990 |
IVL | PI3 | ENSP00000357753 | ENSP00000243924 | involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia (By similarity) | peptidase inhibitor 3, skin-derived; Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis | 0.472 |
IVL | SPRR3 | ENSP00000357753 | ENSP00000295367 | involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia (By similarity) | small proline-rich protein 3 | 0.885 |
KRT1 | CSTA | ENSP00000252244 | ENSP00000264474 | keratin 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). In complex with C1QBP is a high affinty receptor for kininogen-1/HMWK | cystatin A (stefin A); This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis | 0.759 |
KRT1 | EVPL | ENSP00000252244 | ENSP00000301607 | keratin 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). In complex with C1QBP is a high affinty receptor for kininogen-1/HMWK | envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments | 0.678 |
KRT1 | IVL | ENSP00000252244 | ENSP00000357753 | keratin 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). In complex with C1QBP is a high affinty receptor for kininogen-1/HMWK | involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia (By similarity) | 0.908 |