Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | OTC | ornithine carbamoyltransferase (354 aa) | ||
 | ODC1 | ornithine decarboxylase 1 (461 aa) | ||
 | ALDH3B2 | aldehyde dehydrogenase 3 family, member B2 (385 aa) | ||
 | ALDH1L2 | aldehyde dehydrogenase 1 family, member L2 (923 aa) | ||
 | HIBADH | 3-hydroxyisobutyrate dehydrogenase (336 aa) | ||
 | GLUD1 | glutamate dehydrogenase 1; May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity) (558 aa) | ||
 | ALDH4A1 | aldehyde dehydrogenase 4 family, member A1 (563 aa) | ||
 | ALDH16A1 | aldehyde dehydrogenase 16 family, member A1 (802 aa) | ||
 | ALDH1A1 | aldehyde dehydrogenase 1 family, member A1; Binds free retinal and cellular retinol-binding protein- bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity) (501 aa) | ||
 | PRODH2 | proline dehydrogenase (oxidase) 2; Converts proline to delta-1-pyrroline-5-carboxylate (Probable) (536 aa) | ||
 | POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the cen [...] (1970 aa) | ||
 | CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family); Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Isoform 2 may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells (475 aa) | ||
 | PITPNB | phosphatidylinositol transfer protein, beta; Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes (271 aa) | ||
 | PRODH | proline dehydrogenase (oxidase) 1 (600 aa) | ||
 | CNDP1 | carnosine dipeptidase 1 (metallopeptidase M20 family) (507 aa) | ||
 | ERGIC2 | ERGIC and golgi 2; Possible role in transport between endoplasmic reticulum and Golgi (By similarity) (377 aa) | ||
 | OAT | ornithine aminotransferase (439 aa) | ||
 | CTSA | cathepsin A; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins (498 aa) | ||
 | MAP1LC3A | microtubule-associated protein 1 light chain 3 alpha; Involved in formation of autophagosomal vacuoles (autophagosomes) (125 aa) | ||
 | ALDH1B1 | aldehyde dehydrogenase 1 family, member B1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (517 aa) | ||
 | ACY1 | aminoacylase 1; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate) (408 aa) | ||
 | OTUD4 | OTU domain containing 4 (1049 aa) | ||
 | ENSG00000114786 | ABHD14A-ACY1 readthrough (non-protein coding) (509 aa) | ||
 | ENSG00000255154 | Hydroxyacyl-thioester dehydratase type 2, mitochondrial ; Mitochondrial 3-hydroxyacyl-thioester dehydratase, which may be involved in fatty acid biosynthesis (168 aa) | ||
 | ENSG00000255275 | annotation not available (296 aa) | ||
 | ENSG00000269469 | Uncharacterized protein (72 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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