22 items (Homo sapiens) - STRING network view

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	TRIP13	thyroid hormone receptor interactor 13; Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for [...] (432 aa)
	MED31	mediator complex subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (131 aa)
	GORASP2	golgi reassembly stacking protein 2, 55kDa; Plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after mitotic breakdown. May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (452 aa)
	RPA1	replication protein A1, 70kDa; Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing (616 aa)
	USP15	ubiquitin specific peptidase 15; Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear- according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed-21947082). According to another reports, regulates the TGF-beta receptor s [...] (952 aa)
	EED	embryonic ectoderm development; Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates ’Lys-9’ and ’Lys-27’ of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes ’Lys-26’ trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 ’Lys-27’, whereas H3 ’Lys-27’ recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby link [...] (441 aa)
	SCAF4	SR-related CTD-associated factor 4; May act to physically and functionally link transcription and pre-mRNA processing (By similarity) (1147 aa)
	TRA2A	transformer 2 alpha homolog (Drosophila); Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing (282 aa)
	UQCRFS1	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (274 aa)
	TMED9	transmembrane emp24 protein transport domain containing 9; Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer- dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, s [...] (235 aa)
	VMA21	VMA21 vacuolar H+-ATPase homolog (S. cerevisiae); Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum (101 aa)
	PLAUR	plasminogen activator, urokinase receptor (335 aa)
	S100A4	S100 calcium binding protein A4 (101 aa)
	USP33	ubiquitin specific peptidase 33; Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube [...] (942 aa)
	WDHD1	WD repeat and HMG-box DNA binding protein 1; Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication (1129 aa)
	SELENBP1	selenium binding protein 1; Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity) (472 aa)
	SELRC1	Sel1 repeat containing 1 (231 aa)
	DPP7	dipeptidyl-peptidase 7; Plays an important role in the degradation of some oligopeptides (492 aa)
	AR	androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 (920 aa)
	SUCLG1	succinate-CoA ligase, alpha subunit; Catalyzes the ATP- or GTP-dependent ligation of succinate and CoA to form succinyl-CoA. The nature of the beta subunit determines the nucleotide specificity (By similarity) (346 aa)
	SUMO2	SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...] (95 aa)
	GPX1	glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown (203 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	EED	ENSP00000363822	ENSP00000263360	androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3	embryonic ectoderm development; Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates ’Lys-9’ and ’Lys-27’ of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes ’Lys-26’ trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 ’Lys-27’, whereas H3 ’Lys-27’ recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby link [...]	0.405
AR	SELENBP1	ENSP00000363822	ENSP00000357861	androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3	selenium binding protein 1; Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity)	0.590
AR	SUMO2	ENSP00000363822	ENSP00000405965	androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3	SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...]	0.949
DPP7	SELENBP1	ENSP00000360635	ENSP00000357861	dipeptidyl-peptidase 7; Plays an important role in the degradation of some oligopeptides	selenium binding protein 1; Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity)	0.644
EED	AR	ENSP00000263360	ENSP00000363822	embryonic ectoderm development; Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates ’Lys-9’ and ’Lys-27’ of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes ’Lys-26’ trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 ’Lys-27’, whereas H3 ’Lys-27’ recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby link [...]	androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3	0.405
EED	SELENBP1	ENSP00000263360	ENSP00000357861	embryonic ectoderm development; Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates ’Lys-9’ and ’Lys-27’ of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes ’Lys-26’ trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 ’Lys-27’, whereas H3 ’Lys-27’ recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby link [...]	selenium binding protein 1; Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity)	0.401
GPX1	SELENBP1	ENSP00000407375	ENSP00000357861	glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown	selenium binding protein 1; Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity)	0.715
PLAUR	SCAF4	ENSP00000339328	ENSP00000286835	plasminogen activator, urokinase receptor	SR-related CTD-associated factor 4; May act to physically and functionally link transcription and pre-mRNA processing (By similarity)	0.940
PLAUR	SELENBP1	ENSP00000339328	ENSP00000357861	plasminogen activator, urokinase receptor	selenium binding protein 1; Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity)	0.961
PLAUR	VMA21	ENSP00000339328	ENSP00000333255	plasminogen activator, urokinase receptor	VMA21 vacuolar H+-ATPase homolog (S. cerevisiae); Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum	0.944
PLAUR	WDHD1	ENSP00000339328	ENSP00000353793	plasminogen activator, urokinase receptor	WD repeat and HMG-box DNA binding protein 1; Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication	0.894
RPA1	SUMO2	ENSP00000254719	ENSP00000405965	replication protein A1, 70kDa; Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing	SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...]	0.655
S100A4	SELENBP1	ENSP00000346294	ENSP00000357861	S100 calcium binding protein A4	selenium binding protein 1; Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity)	0.675
SCAF4	PLAUR	ENSP00000286835	ENSP00000339328	SR-related CTD-associated factor 4; May act to physically and functionally link transcription and pre-mRNA processing (By similarity)	plasminogen activator, urokinase receptor	0.940
SCAF4	SELENBP1	ENSP00000286835	ENSP00000357861	SR-related CTD-associated factor 4; May act to physically and functionally link transcription and pre-mRNA processing (By similarity)	selenium binding protein 1; Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity)	0.972
SCAF4	SELRC1	ENSP00000286835	ENSP00000360593	SR-related CTD-associated factor 4; May act to physically and functionally link transcription and pre-mRNA processing (By similarity)	Sel1 repeat containing 1	0.970
SCAF4	UQCRFS1	ENSP00000286835	ENSP00000306397	SR-related CTD-associated factor 4; May act to physically and functionally link transcription and pre-mRNA processing (By similarity)	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	0.644
SCAF4	VMA21	ENSP00000286835	ENSP00000333255	SR-related CTD-associated factor 4; May act to physically and functionally link transcription and pre-mRNA processing (By similarity)	VMA21 vacuolar H+-ATPase homolog (S. cerevisiae); Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum	0.970
SELENBP1	AR	ENSP00000357861	ENSP00000363822	selenium binding protein 1; Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity)	androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3	0.590
SELENBP1	DPP7	ENSP00000357861	ENSP00000360635	selenium binding protein 1; Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity)	dipeptidyl-peptidase 7; Plays an important role in the degradation of some oligopeptides	0.644

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