node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CRKL | UBC | ENSP00000346300 | ENSP00000344818 | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | ubiquitin C | 0.927 |
ELAVL1 | UBC | ENSP00000385269 | ENSP00000344818 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | ubiquitin C | 0.998 |
LATS2 | UBC | ENSP00000372035 | ENSP00000344818 | LATS, large tumor suppressor, homolog 2 (Drosophila); Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation in [...] | ubiquitin C | 0.625 |
MPDZ | PLEKHA1 | ENSP00000370410 | ENSP00000357986 | multiple PDZ domain protein | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane | 0.879 |
MPDZ | PLEKHA2 | ENSP00000370410 | ENSP00000393860 | multiple PDZ domain protein | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity) | 0.860 |
MPDZ | SH3BP4 | ENSP00000370410 | ENSP00000340237 | multiple PDZ domain protein | SH3-domain binding protein 4; May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin- mediated endocytosis. Alternatively, may acts as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy | 0.462 |
MPDZ | UBC | ENSP00000370410 | ENSP00000344818 | multiple PDZ domain protein | ubiquitin C | 0.497 |
PLEKHA1 | MPDZ | ENSP00000357986 | ENSP00000370410 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane | multiple PDZ domain protein | 0.879 |
PLEKHA1 | PLEKHA2 | ENSP00000357986 | ENSP00000393860 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity) | 0.603 |
PLEKHA1 | PTPN13 | ENSP00000357986 | ENSP00000394794 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | 0.693 |
PLEKHA1 | UBC | ENSP00000357986 | ENSP00000344818 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane | ubiquitin C | 0.620 |
PLEKHA2 | MPDZ | ENSP00000393860 | ENSP00000370410 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity) | multiple PDZ domain protein | 0.860 |
PLEKHA2 | PLEKHA1 | ENSP00000393860 | ENSP00000357986 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity) | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane | 0.603 |
PLEKHA2 | PTPN13 | ENSP00000393860 | ENSP00000394794 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity) | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | 0.674 |
PTPN13 | PLEKHA1 | ENSP00000394794 | ENSP00000357986 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane | 0.693 |
PTPN13 | PLEKHA2 | ENSP00000394794 | ENSP00000393860 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity) | 0.674 |
PTPN13 | UBC | ENSP00000394794 | ENSP00000344818 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | ubiquitin C | 0.498 |
SH3BP4 | MPDZ | ENSP00000340237 | ENSP00000370410 | SH3-domain binding protein 4; May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin- mediated endocytosis. Alternatively, may acts as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy | multiple PDZ domain protein | 0.462 |
SH3BP4 | UBC | ENSP00000340237 | ENSP00000344818 | SH3-domain binding protein 4; May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin- mediated endocytosis. Alternatively, may acts as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy | ubiquitin C | 0.721 |
UBC | CRKL | ENSP00000344818 | ENSP00000346300 | ubiquitin C | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | 0.927 |