node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APCS | CRP | ENSP00000255040 | ENSP00000255030 | amyloid P component, serum; Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin | C-reactive protein, pentraxin-related; Displays several functions associated with host defense- it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells | 0.827 |
APCS | FCGR1A | ENSP00000255040 | ENSP00000358165 | amyloid P component, serum; Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin | Fc fragment of IgG, high affinity Ia, receptor (CD64) | 0.566 |
APCS | FCGR3A | ENSP00000255040 | ENSP00000356946 | amyloid P component, serum; Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin | Fc fragment of IgG, low affinity IIIa, receptor (CD16a); Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis | 0.670 |
CRKL | FCGR1A | ENSP00000346300 | ENSP00000358165 | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | Fc fragment of IgG, high affinity Ia, receptor (CD64) | 0.567 |
CRKL | HCK | ENSP00000346300 | ENSP00000365012 | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | hemopoietic cell kinase | 0.701 |
CRKL | SYK | ENSP00000346300 | ENSP00000364898 | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | spleen tyrosine kinase; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine- phosphorylated ITAM domains. The association with the receptor can also [...] | 0.963 |
CRP | APCS | ENSP00000255030 | ENSP00000255040 | C-reactive protein, pentraxin-related; Displays several functions associated with host defense- it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells | amyloid P component, serum; Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin | 0.827 |
CRP | FCGR1A | ENSP00000255030 | ENSP00000358165 | C-reactive protein, pentraxin-related; Displays several functions associated with host defense- it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells | Fc fragment of IgG, high affinity Ia, receptor (CD64) | 0.576 |
FCAR | FCGR1A | ENSP00000347714 | ENSP00000358165 | Fc fragment of IgA, receptor for | Fc fragment of IgG, high affinity Ia, receptor (CD64) | 0.576 |
FCGR1A | APCS | ENSP00000358165 | ENSP00000255040 | Fc fragment of IgG, high affinity Ia, receptor (CD64) | amyloid P component, serum; Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin | 0.566 |
FCGR1A | CRKL | ENSP00000358165 | ENSP00000346300 | Fc fragment of IgG, high affinity Ia, receptor (CD64) | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | 0.567 |
FCGR1A | CRP | ENSP00000358165 | ENSP00000255030 | Fc fragment of IgG, high affinity Ia, receptor (CD64) | C-reactive protein, pentraxin-related; Displays several functions associated with host defense- it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells | 0.576 |
FCGR1A | FCAR | ENSP00000358165 | ENSP00000347714 | Fc fragment of IgG, high affinity Ia, receptor (CD64) | Fc fragment of IgA, receptor for | 0.576 |
FCGR1A | FCGR3A | ENSP00000358165 | ENSP00000356946 | Fc fragment of IgG, high affinity Ia, receptor (CD64) | Fc fragment of IgG, low affinity IIIa, receptor (CD16a); Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis | 0.653 |
FCGR1A | HCK | ENSP00000358165 | ENSP00000365012 | Fc fragment of IgG, high affinity Ia, receptor (CD64) | hemopoietic cell kinase | 0.618 |
FCGR1A | HRG | ENSP00000358165 | ENSP00000232003 | Fc fragment of IgG, high affinity Ia, receptor (CD64) | histidine-rich glycoprotein; Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan sulfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-sulfated polysaccharide chains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and is implicated in regulating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell [...] | 0.576 |
FCGR1A | LAT | ENSP00000358165 | ENSP00000378845 | Fc fragment of IgG, high affinity Ia, receptor (CD64) | linker for activation of T cells; Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization [...] | 0.576 |
FCGR1A | LILRB2 | ENSP00000358165 | ENSP00000375629 | Fc fragment of IgG, high affinity Ia, receptor (CD64) | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2; Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions | 0.576 |
FCGR1A | SYK | ENSP00000358165 | ENSP00000364898 | Fc fragment of IgG, high affinity Ia, receptor (CD64) | spleen tyrosine kinase; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine- phosphorylated ITAM domains. The association with the receptor can also [...] | 0.576 |
FCGR3A | APCS | ENSP00000356946 | ENSP00000255040 | Fc fragment of IgG, low affinity IIIa, receptor (CD16a); Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis | amyloid P component, serum; Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin | 0.670 |