Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
KIF13B KIF13B KIF14 KIF14 KIF1A KIF1A KIF1C KIF1C CDK5RAP3 CDK5RAP3 UFL1 UFL1 UBE2E1 UBE2E1 CLIP4 CLIP4 KIF13A KIF13A DDRGK1 DDRGK1 UBE2D1 UBE2D1 UBC UBC STARD9 STARD9 KIF1B KIF1B ZNF622 ZNF622 UBE2E3 UBE2E3 ENSG00000264324 ENSG00000264324 FUS FUS UBE2D4 UBE2D4 DCTN1 DCTN1 NAV3 NAV3 CLIP2 CLIP2 CLIP3 CLIP3 CLIP1 CLIP1 KIF16B KIF16B NAV2 NAV2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
UBE2D4ubiquitin-conjugating enzyme E2D 4 (putative); Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer ’Lys-11’ and ’Lys-48’-linked polyubiquitination (147 aa)
CLIP2CAP-GLY domain containing linker protein 2 (1046 aa)
FUSfused in sarcoma; Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single- stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity (526 aa)
KIF13Akinesin family member 13A (1805 aa)
KIF1Bkinesin family member 1B (1770 aa)
STARD9StAR-related lipid transfer (START) domain containing 9; Microtubule-dependent motor protein required for spindle pole assembly during mitosis. Required to stabilize the pericentriolar material (PCM) (4700 aa)
CLIP1CAP-GLY domain containing linker protein 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking (1427 aa)
UBE2E1ubiquitin-conjugating enzyme E2E 1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes ’Lys-48’-linked polyubiquitination (193 aa)
ZNF622zinc finger protein 622; May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development (477 aa)
KIF1Ckinesin family member 1C; Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end- directed motility (1103 aa)
KIF1Akinesin family member 1A (1690 aa)
CLIP4CAP-GLY domain containing linker protein family, member 4 (705 aa)
CDK5RAP3CDK5 regulatory subunit associated protein 3; Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1 (By similarity) (506 aa)
UBCubiquitin C (685 aa)
DDRGK1DDRGK domain containing 1 (314 aa)
CLIP3CAP-GLY domain containing linker protein 3; Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics (547 aa)
DCTN1dynactin 1 (1278 aa)
KIF14kinesin family member 14; Plays an essential role in cytokinesis (1648 aa)
UFL1UFM1-specific ligase 1; E3 UFM1-protein ligase that mediates ufmylation of target proteins such as DDRGK1/C20orf116. The function of ufmylation is unknown. May act as a tumor suppressor by inhibiting cell invasion, blocking NF-kappa-B signaling and increasing stability of CDK5RAP3 (794 aa)
UBE2D1ubiquitin-conjugating enzyme E2D 1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 48’-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyu [...] (147 aa)
UBE2E3ubiquitin-conjugating enzyme E2E 3; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 11’- and ’Lys-48’-, as well as ’Lys-63’-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest (207 aa)
NAV2neuron navigator 2 (2432 aa)
KIF16Bkinesin family member 16B (1392 aa)
ENSG00000264324Uncharacterized protein (191 aa)
KIF13Bkinesin family member 13B; Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes (1826 aa)
NAV3neuron navigator 3; May regulate IL2 production by T-cells. May be involved in neuron regeneration (2363 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (32%)