10 items (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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protein of unknown 3D structure

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some 3D structure is known or predicted

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Known Interactions

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Your Input:
	PEPD	peptidase D (493 aa)
	ASS1	argininosuccinate synthase 1; Is indirectly involved in the control of blood pressure (By similarity) (412 aa)
	CEP76	centrosomal protein 76kDa; Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication (659 aa)
	ATG3	autophagy related 3; E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation to ATG8-like proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1- E2 complex with ATG3 (314 aa)
	UBC	ubiquitin C (685 aa)
	DPP3	dipeptidyl-peptidase 3; Cleaves Arg-Arg-beta-naphthylamide (737 aa)
	NHLRC2	NHL repeat containing 2 (726 aa)
	ACOT7	acyl-CoA thioesterase 7 (380 aa)
	DAK	dihydroxyacetone kinase 2 homolog (S. cerevisiae); Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate (575 aa)
	TNFAIP8	tumor necrosis factor, alpha-induced protein 8; Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation (198 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACOT7	NHLRC2	ENSP00000367086	ENSP00000358307	acyl-CoA thioesterase 7	NHL repeat containing 2	0.412
ACOT7	TNFAIP8	ENSP00000367086	ENSP00000421848	acyl-CoA thioesterase 7	tumor necrosis factor, alpha-induced protein 8; Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation	0.418
ACOT7	UBC	ENSP00000367086	ENSP00000344818	acyl-CoA thioesterase 7	ubiquitin C	0.922
ASS1	ATG3	ENSP00000253004	ENSP00000283290	argininosuccinate synthase 1; Is indirectly involved in the control of blood pressure (By similarity)	autophagy related 3; E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation to ATG8-like proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1- E2 complex with ATG3	0.538
ASS1	DPP3	ENSP00000253004	ENSP00000353701	argininosuccinate synthase 1; Is indirectly involved in the control of blood pressure (By similarity)	dipeptidyl-peptidase 3; Cleaves Arg-Arg-beta-naphthylamide	0.485
ASS1	NHLRC2	ENSP00000253004	ENSP00000358307	argininosuccinate synthase 1; Is indirectly involved in the control of blood pressure (By similarity)	NHL repeat containing 2	0.538
ASS1	PEPD	ENSP00000253004	ENSP00000244137	argininosuccinate synthase 1; Is indirectly involved in the control of blood pressure (By similarity)	peptidase D	0.501
ASS1	TNFAIP8	ENSP00000253004	ENSP00000421848	argininosuccinate synthase 1; Is indirectly involved in the control of blood pressure (By similarity)	tumor necrosis factor, alpha-induced protein 8; Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation	0.482
ASS1	UBC	ENSP00000253004	ENSP00000344818	argininosuccinate synthase 1; Is indirectly involved in the control of blood pressure (By similarity)	ubiquitin C	0.890
ATG3	ASS1	ENSP00000283290	ENSP00000253004	autophagy related 3; E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation to ATG8-like proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1- E2 complex with ATG3	argininosuccinate synthase 1; Is indirectly involved in the control of blood pressure (By similarity)	0.538
ATG3	NHLRC2	ENSP00000283290	ENSP00000358307	autophagy related 3; E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation to ATG8-like proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1- E2 complex with ATG3	NHL repeat containing 2	0.538
ATG3	TNFAIP8	ENSP00000283290	ENSP00000421848	autophagy related 3; E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation to ATG8-like proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1- E2 complex with ATG3	tumor necrosis factor, alpha-induced protein 8; Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation	0.538
ATG3	UBC	ENSP00000283290	ENSP00000344818	autophagy related 3; E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation to ATG8-like proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1- E2 complex with ATG3	ubiquitin C	0.832
DAK	NHLRC2	ENSP00000378360	ENSP00000358307	dihydroxyacetone kinase 2 homolog (S. cerevisiae); Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate	NHL repeat containing 2	0.414
DAK	UBC	ENSP00000378360	ENSP00000344818	dihydroxyacetone kinase 2 homolog (S. cerevisiae); Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate	ubiquitin C	0.868
DPP3	ASS1	ENSP00000353701	ENSP00000253004	dipeptidyl-peptidase 3; Cleaves Arg-Arg-beta-naphthylamide	argininosuccinate synthase 1; Is indirectly involved in the control of blood pressure (By similarity)	0.485
DPP3	NHLRC2	ENSP00000353701	ENSP00000358307	dipeptidyl-peptidase 3; Cleaves Arg-Arg-beta-naphthylamide	NHL repeat containing 2	0.538
DPP3	PEPD	ENSP00000353701	ENSP00000244137	dipeptidyl-peptidase 3; Cleaves Arg-Arg-beta-naphthylamide	peptidase D	0.498
DPP3	TNFAIP8	ENSP00000353701	ENSP00000421848	dipeptidyl-peptidase 3; Cleaves Arg-Arg-beta-naphthylamide	tumor necrosis factor, alpha-induced protein 8; Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation	0.538
DPP3	UBC	ENSP00000353701	ENSP00000344818	dipeptidyl-peptidase 3; Cleaves Arg-Arg-beta-naphthylamide	ubiquitin C	0.826

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