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MKI67IP | MKI67 (FHA domain) interacting nucleolar phosphoprotein (293 aa) | |||
LRRK2 | leucine-rich repeat kinase 2; May play a role in the phosphorylation of proteins central to Parkinson disease. Phosphorylates PRDX3. May also have GTPase activity. Positively regulates autophagy through a calcium- dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (2527 aa) | |||
PELP1 | proline, glutamate and leucine rich protein 1; Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence- specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth [...] (1274 aa) | |||
PA2G4 | proliferation-associated 2G4, 38kDa; May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in [...] (394 aa) | |||
POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each ot [...] (1174 aa) | |||
ME2 | malic enzyme 2, NAD(+)-dependent, mitochondrial (584 aa) | |||
GNL3L | guanine nucleotide binding protein-like 3 (nucleolar)-like; Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal pr [...] (582 aa) | |||
UBC | ubiquitin C (685 aa) | |||
PES1 | pescadillo ribosomal biogenesis factor 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome (588 aa) | |||
SDAD1 | SDA1 domain containing 1; Required for 60S pre-ribosomal subunits export to the cytoplasm (By similarity) (687 aa) | |||
ME3 | malic enzyme 3, NADP(+)-dependent, mitochondrial (604 aa) | |||
GTPBP4 | GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity) (634 aa) | |||
MDN1 | MDN1, midasin homolog (yeast); Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (By similarity) (5596 aa) | |||
ME1 | malic enzyme 1, NADP(+)-dependent, cytosolic (572 aa) | |||
RAE1 | RAE1 RNA export 1 homolog (S. pombe); Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton (368 aa) | |||
DDX27 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 (796 aa) | |||
SET | SET nuclear oncogene; Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T- lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibilit [...] (290 aa) | |||
GNL2 | guanine nucleotide binding protein-like 2 (nucleolar); GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity) (731 aa) | |||
TEX10 | testis expressed 10; Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (929 aa) | |||
KIAA0664 | KIAA0664; Involved in proper cytoplasmic distribution of mitochondria (By similarity) (1309 aa) | |||
GNL3 | guanine nucleotide binding protein-like 3 (nucleolar); May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity) (549 aa) | |||
NLE1 | notchless homolog 1 (Drosophila) (485 aa) | |||
SRP19 | signal recognition particle 19kDa; Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP (144 aa) | |||
ENSG00000257411 | Uncharacterized protein (163 aa) | |||
TUBB3 | tubulin, beta 3 class III; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity) (797 aa) | |||
RSL1D1 | ribosomal L1 domain containing 1 (490 aa) |