Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
PWP2 PWP2 DIRAS3 DIRAS3 ARMC4 ARMC4 RAP2C RAP2C GOT2 GOT2 RASL11A RASL11A RASL12 RASL12 RASL10B RASL10B HAS2 HAS2 RASD1 RASD1 HAS3 HAS3 UBC UBC GNB1 GNB1 ENSG00000248354 ENSG00000248354 GNB4 GNB4 ETF1 ETF1 RASD2 RASD2 GNB2 GNB2 LRRK2 LRRK2 ZDHHC6 ZDHHC6 KHDRBS1 KHDRBS1 RTDR1 RTDR1 HAS1 HAS1 FOXK1 FOXK1 GNB3 GNB3 FOXK2 FOXK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
RTDR1rhabdoid tumor deletion region gene 1 (348 aa)
RASD2RASD family, member 2; GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination (266 aa)
RASL12RAS-like, family 12 (266 aa)
HAS1hyaluronan synthase 1; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis. Also able to catalyze the synthesis of chito- oligosaccharide depending on the substrate (578 aa)
RASD1RAS, dexamethasone-induced 1; Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity) (281 aa)
GNB3guanine nucleotide binding protein (G protein), beta polypeptide 3; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (340 aa)
GNB4guanine nucleotide binding protein (G protein), beta polypeptide 4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (340 aa)
RASL11ARAS-like, family 11, member A; Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription (By similarity) (242 aa)
GOT2glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (430 aa)
RASL10BRAS-like, family 10, member B; May facilitate the release of atrial natriuretic peptide by cardiomyocytes and hence play a role in the regulation of arterial pressure (By similarity) (203 aa)
PWP2PWP2 periodic tryptophan protein homolog (yeast) (919 aa)
LRRK2leucine-rich repeat kinase 2; May play a role in the phosphorylation of proteins central to Parkinson disease. Phosphorylates PRDX3. May also have GTPase activity. Positively regulates autophagy through a calcium- dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (2527 aa)
HAS3hyaluronan synthase 3; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis (553 aa)
GNB2guanine nucleotide binding protein (G protein), beta polypeptide 2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (340 aa)
ARMC4armadillo repeat containing 4 (1044 aa)
HAS2hyaluronan synthase 2; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis (552 aa)
KHDRBS1KH domain containing, RNA binding, signal transduction associated 1; Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain- containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA n [...] (443 aa)
FOXK1forkhead box K1; Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Has a role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity) (733 aa)
FOXK2forkhead box K2; Recognizes the core sequence 5’-TAAACA-3’. Binds to NFAT-like motifs (purine-rich) in the IL2 promoter. Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (660 aa)
RAP2CRAP2C, member of RAS oncogene family; Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription (183 aa)
UBCubiquitin C (685 aa)
ETF1eukaryotic translation termination factor 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (437 aa)
ZDHHC6zinc finger, DHHC-type containing 6; Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins (413 aa)
DIRAS3DIRAS family, GTP-binding RAS-like 3 (229 aa)
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (340 aa)
ENSG00000248354Uncharacterized protein (205 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: medium (46%)