node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DAZAP2 | UBC | ENSP00000448051 | ENSP00000344818 | DAZ associated protein 2 | ubiquitin C | 0.891 |
ELAVL1 | PARK2 | ENSP00000385269 | ENSP00000355865 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | 0.508 |
ELAVL1 | UBC | ENSP00000385269 | ENSP00000344818 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | ubiquitin C | 0.998 |
FAM46C | MVP | ENSP00000358458 | ENSP00000349977 | family with sequence similarity 46, member C; Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon | major vault protein; Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases | 0.661 |
FAM46C | PLK4 | ENSP00000358458 | ENSP00000270861 | family with sequence similarity 46, member C; Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon | polo-like kinase 4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates ’Ser-151’ of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to u [...] | 0.410 |
FAM46C | UBC | ENSP00000358458 | ENSP00000344818 | family with sequence similarity 46, member C; Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon | ubiquitin C | 0.483 |
MVP | FAM46C | ENSP00000349977 | ENSP00000358458 | major vault protein; Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases | family with sequence similarity 46, member C; Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon | 0.661 |
MVP | UBC | ENSP00000349977 | ENSP00000344818 | major vault protein; Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases | ubiquitin C | 0.724 |
PARK2 | ELAVL1 | ENSP00000355865 | ENSP00000385269 | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | 0.508 |
PARK2 | UBC | ENSP00000355865 | ENSP00000344818 | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | ubiquitin C | 0.999 |
PLK4 | FAM46C | ENSP00000270861 | ENSP00000358458 | polo-like kinase 4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates ’Ser-151’ of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to u [...] | family with sequence similarity 46, member C; Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon | 0.410 |
PLK4 | UBC | ENSP00000270861 | ENSP00000344818 | polo-like kinase 4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates ’Ser-151’ of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to u [...] | ubiquitin C | 0.438 |
PMPCB | UBC | ENSP00000249269 | ENSP00000344818 | peptidase (mitochondrial processing) beta; Cleaves presequences (transit peptides) from mitochondrial protein precursors (By similarity) | ubiquitin C | 0.547 |
TRIP6 | UBC | ENSP00000200457 | ENSP00000344818 | thyroid hormone receptor interactor 6; Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor | ubiquitin C | 0.483 |
UBC | DAZAP2 | ENSP00000344818 | ENSP00000448051 | ubiquitin C | DAZ associated protein 2 | 0.891 |
UBC | ELAVL1 | ENSP00000344818 | ENSP00000385269 | ubiquitin C | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | 0.998 |
UBC | FAM46C | ENSP00000344818 | ENSP00000358458 | ubiquitin C | family with sequence similarity 46, member C; Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon | 0.483 |
UBC | MVP | ENSP00000344818 | ENSP00000349977 | ubiquitin C | major vault protein; Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases | 0.724 |
UBC | PARK2 | ENSP00000344818 | ENSP00000355865 | ubiquitin C | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | 0.999 |
UBC | PLK4 | ENSP00000344818 | ENSP00000270861 | ubiquitin C | polo-like kinase 4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates ’Ser-151’ of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to u [...] | 0.438 |