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GAPVD1 GAPVD1 ECI2 ECI2 ADH1B ADH1B ADH5 ADH5 CERS3 CERS3 DMC1 DMC1 SSRP1 SSRP1 ADH1A ADH1A RAN RAN RAD51 RAD51 CERS4 CERS4 RAD51D RAD51D KCTD7 KCTD7 RAD51B RAD51B ENSG00000267618 ENSG00000267618 CERS2 CERS2 RABGEF1 RABGEF1 RAB39B RAB39B BUB1 BUB1 CERS6 CERS6 CERS5 CERS5 ADH7 ADH7 ADH6 ADH6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
ADH1Aalcohol dehydrogenase 1A (class I), alpha polypeptide (375 aa)
DMC1DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast); May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks (By similarity) (340 aa)
CERS4ceramide synthase 4; May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity) (394 aa)
CERS2ceramide synthase 2; Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis (380 aa)
SSRP1structure specific recognition protein 1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the ree [...] (709 aa)
CERS3ceramide synthase 3; May be involved in sphingolipid synthesis or its regulation (By similarity) (383 aa)
RABGEF1RAB guanine nucleotide exchange factor (GEF) 1; Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity) (491 aa)
ADH5alcohol dehydrogenase 5 (class III), chi polypeptide; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (374 aa)
BUB1budding uninhibited by benzimidazoles 1 homolog (yeast); Serine/threonine-protein kinase that performs 2 crucial functions during mitosis- it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Plays an important role in defining SGOL1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting compl [...] (1085 aa)
CERS6ceramide synthase 6; May be involved in sphingolipid synthesis or its regulation (By similarity) (384 aa)
ADH1Balcohol dehydrogenase 1B (class I), beta polypeptide (375 aa)
CERS5ceramide synthase 5; May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl- (C16) ceramide) in a fumonisin B1-independent manner (By similarity) (392 aa)
RAB39BRAB39B, member RAS oncogene family; May be involved in vesicular trafficking. Plays a role in synapse formation (By similarity) (213 aa)
ECI2enoyl-CoA delta isomerase 2 (394 aa)
RAD51RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3 (340 aa)
RANRAN, member RAS oncogene family (216 aa)
GAPVD1GTPase activating protein and VPS9 domains 1 (1487 aa)
ADH6alcohol dehydrogenase 6 (class V) (375 aa)
KCTD7potassium channel tetramerisation domain containing 7; Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity) (491 aa)
RAD51BRAD51 homolog B (S. cerevisiae) (384 aa)
ADH7alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide; Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism (394 aa)
RAD51DRAD51 homolog D (S. cerevisiae) (348 aa)
ENSG00000267618Uncharacterized protein (272 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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