Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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 | AES | amino-terminal enhancer of split; Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state (264 aa) | ||
 | USHBP1 | Usher syndrome 1C binding protein 1 (703 aa) | ||
 | GFAP | glial fibrillary acidic protein (432 aa) | ||
 | GSE1 | Gse1 coiled-coil protein homolog (mouse) (1217 aa) | ||
 | RNF138 | ring finger protein 138, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (245 aa) | ||
 | ZBTB32 | zinc finger and BTB domain containing 32; DNA-binding protein that binds to the to a 5’- TGTACAGTGT-3’ core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells (By similarity) (487 aa) | ||
 | SOX30 | SRY (sex determining region Y)-box 30; Transcriptional activator. Binds to the DNA sequence 5’- ACAAT-3’ and shows a preference for guanine residues surrounding this core motif (753 aa) | ||
 | NARF | nuclear prelamin A recognition factor (456 aa) | ||
 | KLHL3 | kelch-like 3 (Drosophila); Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex may act by mediating ubiquitination of SLC12A3/NCC, thereby regulating SLC12A3/NCC subcellular location at the cell membrane (587 aa) | ||
 | GLYR1 | glyoxylate reductase 1 homolog (Arabidopsis) (553 aa) | ||
 | GPRASP2 | G protein-coupled receptor associated sorting protein 2; May play a role in regulation of a variety of G-protein coupled receptors (838 aa) | ||
 | TMCC2 | transmembrane and coiled-coil domain family 2 (709 aa) | ||
 | CEP57L1 | centrosomal protein 57kDa-like 1; Centrosomal protein which may be required for microtubule attachment to centrosomes (By similarity) (460 aa) | ||
 | SAMD3 | sterile alpha motif domain containing 3 (520 aa) | ||
 | C6orf165 | chromosome 6 open reading frame 165 (622 aa) | ||
 | UBXN11 | UBX domain protein 11 (520 aa) | ||
 | TP73 | tumor protein p73; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) (636 aa) | ||
 | APIP | APAF1 interacting protein; Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death (By similarity) (242 aa) | ||
 | ROCK1 | Rho-associated, coiled-coil containing protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induc [...] (1354 aa) | ||
 | C1orf94 | chromosome 1 open reading frame 94 (598 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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