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RNF138 | ring finger protein 138, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (245 aa) | |||
ZBTB32 | zinc finger and BTB domain containing 32; DNA-binding protein that binds to the to a 5’- TGTACAGTGT-3’ core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells (By similarity) (487 aa) | |||
SOX30 | SRY (sex determining region Y)-box 30; Transcriptional activator. Binds to the DNA sequence 5’- ACAAT-3’ and shows a preference for guanine residues surrounding this core motif (753 aa) | |||
NARF | nuclear prelamin A recognition factor (456 aa) | |||
KLHL3 | kelch-like 3 (Drosophila); Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex may act by mediating ubiquitination of SLC12A3/NCC, thereby regulating SLC12A3/NCC subcellular location at the cell membrane (587 aa) | |||
GLYR1 | glyoxylate reductase 1 homolog (Arabidopsis) (553 aa) | |||
WFIKKN1 | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1; Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity) (548 aa) | |||
GPRASP2 | G protein-coupled receptor associated sorting protein 2; May play a role in regulation of a variety of G-protein coupled receptors (838 aa) | |||
SAMD3 | sterile alpha motif domain containing 3 (520 aa) | |||
C6orf165 | chromosome 6 open reading frame 165 (622 aa) | |||
UBXN11 | UBX domain protein 11 (520 aa) | |||
ROCK1 | Rho-associated, coiled-coil containing protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induc [...] (1354 aa) | |||
C1orf94 | chromosome 1 open reading frame 94 (598 aa) |