node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDC5L | TRAF3IP1 | ENSP00000360532 | ENSP00000362424 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | TNF receptor-associated factor 3 interacting protein 1; Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules | 0.439 |
CDC5L | UBC | ENSP00000360532 | ENSP00000344818 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | ubiquitin C | 0.740 |
DTNBP1 | UBC | ENSP00000341680 | ENSP00000344818 | dystrobrevin binding protein 1; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 fun [...] | ubiquitin C | 0.688 |
EXOC1 | UBC | ENSP00000326514 | ENSP00000344818 | exocyst complex component 1; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane | ubiquitin C | 0.584 |
MRFAP1L1 | UBC | ENSP00000318154 | ENSP00000344818 | Morf4 family associated protein 1-like 1 | ubiquitin C | 0.795 |
NDC80 | UBC | ENSP00000261597 | ENSP00000344818 | NDC80 kinetochore complex component homolog (S. cerevisiae); Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore | ubiquitin C | 0.922 |
RAD51 | RAD51B | ENSP00000372088 | ENSP00000419471 | RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3 | RAD51 homolog B (S. cerevisiae) | 0.700 |
RAD51 | RAD51C | ENSP00000372088 | ENSP00000336701 | RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3 | RAD51 homolog C (S. cerevisiae); Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Participates in branch migration and Holliday junction resolution and thus is important for processing HR intermediates late in t [...] | 0.998 |
RAD51 | RAD51D | ENSP00000372088 | ENSP00000466399 | RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3 | RAD51 homolog D (S. cerevisiae) | 0.682 |
RAD51 | SFR1 | ENSP00000372088 | ENSP00000358742 | RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3 | SWI5-dependent recombination repair 1; Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination | 0.663 |
RAD51 | SWI5 | ENSP00000372088 | ENSP00000316609 | RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3 | SWI5 recombination repair homolog (yeast); Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination | 0.656 |
RAD51 | UBC | ENSP00000372088 | ENSP00000344818 | RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3 | ubiquitin C | 0.652 |
RAD51 | XRCC2 | ENSP00000372088 | ENSP00000352271 | RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3 | X-ray repair complementing defective repair in Chinese hamster cells 2; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA | 0.719 |
RAD51 | XRCC3 | ENSP00000372088 | ENSP00000343392 | RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3 | X-ray repair complementing defective repair in Chinese hamster cells 3; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C | 0.991 |
RAD51B | RAD51 | ENSP00000419471 | ENSP00000372088 | RAD51 homolog B (S. cerevisiae) | RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3 | 0.700 |
RAD51B | RAD51C | ENSP00000419471 | ENSP00000336701 | RAD51 homolog B (S. cerevisiae) | RAD51 homolog C (S. cerevisiae); Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Participates in branch migration and Holliday junction resolution and thus is important for processing HR intermediates late in t [...] | 0.999 |
RAD51B | RAD51D | ENSP00000419471 | ENSP00000466399 | RAD51 homolog B (S. cerevisiae) | RAD51 homolog D (S. cerevisiae) | 0.997 |
RAD51B | SFR1 | ENSP00000419471 | ENSP00000358742 | RAD51 homolog B (S. cerevisiae) | SWI5-dependent recombination repair 1; Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination | 0.905 |
RAD51B | SWI5 | ENSP00000419471 | ENSP00000316609 | RAD51 homolog B (S. cerevisiae) | SWI5 recombination repair homolog (yeast); Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination | 0.905 |
RAD51B | XRCC2 | ENSP00000419471 | ENSP00000352271 | RAD51 homolog B (S. cerevisiae) | X-ray repair complementing defective repair in Chinese hamster cells 2; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA | 0.987 |