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STRINGSTRING
DDX31 DDX31 DHX37 DHX37 PWP2 PWP2 WDR75 WDR75 UBC UBC NOL6 NOL6 PWP1 PWP1 NOP14 NOP14 FBL FBL MPHOSPH10 MPHOSPH10 BRIX1 BRIX1 PDCD11 PDCD11 CEBPZ CEBPZ NOP56 NOP56 KRR1 KRR1 NOC2L NOC2L NOC4L NOC4L NOP58 NOP58 NOP2 NOP2 DDX24 DDX24 RRP12 RRP12 MKI67IP MKI67IP WDR12 WDR12 KIAA0020 KIAA0020 DKC1 DKC1 RBM34 RBM34
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
FBLfibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (321 aa)
KRR1KRR1, small subunit (SSU) processome component, homolog (yeast); Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity) (381 aa)
CEBPZCCAAT/enhancer binding protein (C/EBP), zeta; Stimulates transcription from the HSP70 promoter (1054 aa)
MPHOSPH10M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein); Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (681 aa)
WDR12WD repeat domain 12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome (423 aa)
NOP58NOP58 ribonucleoprotein homolog (yeast); Required for 60S ribosomal subunit biogenesis (By similarity) (529 aa)
MKI67IPMKI67 (FHA domain) interacting nucleolar phosphoprotein (293 aa)
PWP2PWP2 periodic tryptophan protein homolog (yeast) (919 aa)
NOL6nucleolar protein family 6 (RNA-associated) (1146 aa)
DHX37DEAH (Asp-Glu-Ala-His) box polypeptide 37 (1157 aa)
WDR75WD repeat domain 75 (830 aa)
NOP14NOP14 nucleolar protein homolog (yeast); Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity) (857 aa)
NOC2Lnucleolar complex associated 2 homolog (S. cerevisiae); Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter (749 aa)
DDX24DEAD (Asp-Glu-Ala-Asp) box polypeptide 24; ATP-dependent RNA helicase (Potential) (859 aa)
NOC4Lnucleolar complex associated 4 homolog (S. cerevisiae) (516 aa)
BRIX1BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit (353 aa)
UBCubiquitin C (685 aa)
DKC1dyskeratosis congenita 1, dyskerin; Isoform 1- Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (’psi’) residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomera [...] (514 aa)
PDCD11programmed cell death 11; Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA (1871 aa)
RRP12ribosomal RNA processing 12 homolog (S. cerevisiae) (1297 aa)
DDX31DEAD (Asp-Glu-Ala-Asp) box polypeptide 31 (851 aa)
NOP56NOP56 ribonucleoprotein homolog (yeast); Involved in the early to middle stages of 60S ribosomal subunit biogenesis (594 aa)
KIAA0020KIAA0020 (648 aa)
NOP2NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase (808 aa)
RBM34RNA binding motif protein 34 (430 aa)
PWP1PWP1 homolog (S. cerevisiae); May play an important role in cell growth and/or transcription (501 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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