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SEMA7A SEMA7A SEMA4C SEMA4C SEMA4G SEMA4G SEMA3G SEMA3G SEMA3C SEMA3C SEMA3D SEMA3D SEMA3F SEMA3F SEMA6B SEMA6B IGDCC3 IGDCC3 SEMA3E SEMA3E PRTG PRTG LRRC4C LRRC4C UNC5CL UNC5CL SEMA3A SEMA3A NTNG1 NTNG1 UNC5A UNC5A LRRC4 LRRC4 UNC5C UNC5C UNC5D UNC5D FNDC1 FNDC1 UNC5B UNC5B EWSR1 EWSR1 DCC DCC IGDCC4 IGDCC4 NEO1 NEO1 NID1 NID1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
SEMA3Fsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F; May play a role in cell motility and cell adhesion (785 aa)
SEMA4Gsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G; Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity) (843 aa)
SEMA3Gsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G; Has chemorepulsive activities for sympathetic axons. Ligand of NRP2 (By similarity) (782 aa)
UNC5CLunc-5 homolog C (C. elegans)-like; Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets (518 aa)
LRRC4leucine rich repeat containing 4; Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays a important role for auditory synaptic responses. Involved in the suppression of glioma (By similarity) (653 aa)
NEO1neogenin 1; May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues (1461 aa)
SEMA7Asemaphorin 7A, GPI membrane anchor (John Milton Hagen blood group); Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and [...] (666 aa)
NID1nidogen 1; Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell- extracellular matrix interactions (1247 aa)
SEMA3Csema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C; Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity) (751 aa)
SEMA3Asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A; Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1 (771 aa)
LRRC4Cleucine rich repeat containing 4C; May promote neurite outgrowth of developing thalamic neurons (640 aa)
SEMA3Dsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D; Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin (By similarity) (777 aa)
FNDC1fibronectin type III domain containing 1 (1894 aa)
SEMA6Bsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B; May play a role in both peripheral and central nervous system development (By similarity) (888 aa)
SEMA3Esema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down- regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity [...] (775 aa)
SEMA4Csema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C; Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at ’Tyr-1248’. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade (833 aa)
IGDCC4immunoglobulin superfamily, DCC subclass, member 4 (1250 aa)
UNC5Aunc-5 homolog A (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (842 aa)
IGDCC3immunoglobulin superfamily, DCC subclass, member 3 (814 aa)
UNC5Bunc-5 homolog B (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (945 aa)
NTNG1netrin G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites (539 aa)
PRTGprotogenin; May play a role in anteroposterior axis elongation (By similarity) (1150 aa)
UNC5Dunc-5 homolog D (C. elegans); Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity) (953 aa)
DCCdeleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene (1447 aa)
EWSR1Ewing sarcoma breakpoint region 1; Might normally function as a transcriptionnal repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes (661 aa)
UNC5Cunc-5 homolog C (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity) (931 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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