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UBR7 | ubiquitin protein ligase E3 component n-recognin 7 (putative); E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity) (425 aa) | |||
FBL | fibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (321 aa) | |||
DAZAP1 | DAZ associated protein 1; RNA-binding protein, which may be required during spermatogenesis (407 aa) | |||
SRSF6 | serine/arginine-rich splicing factor 6; Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10 (344 aa) | |||
PIAS1 | protein inhibitor of activated STAT, 1; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activ [...] (651 aa) | |||
ZC3H14 | zinc finger CCCH-type containing 14 (736 aa) | |||
MSI1 | musashi homolog 1 (Drosophila); RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5’- GUUAGUUAGUUAGUU-3’ and other sequences containing the pattern 5’- [GA]U(1-3)AGU-3’. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity) (362 aa) | |||
KIF9 | kinesin family member 9 (790 aa) | |||
ZCCHC14 | zinc finger, CCHC domain containing 14 (949 aa) | |||
LSM14B | LSM14B, SCD6 homolog B (S. cerevisiae); May play a role in control of mRNA translation (By similarity) (385 aa) | |||
MSI2 | musashi homolog 2 (Drosophila); RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity) (328 aa) | |||
HMGA1 | high mobility group AT-hook 1; HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3’-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions (107 aa) | |||
GMPPB | GDP-mannose pyrophosphorylase B (387 aa) | |||
PABPC1 | poly(A) binding protein, cytoplasmic 1; Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre- mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability [...] (636 aa) | |||
HIST4H4 | histone cluster 4, H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (103 aa) | |||
HIST2H2AA3 | histone cluster 2, H2aa3 (130 aa) | |||
PRMT6 | protein arginine methyltransferase 6; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 ’Arg-2’ to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on hi [...] (375 aa) | |||
SRSF4 | serine/arginine-rich splicing factor 4; Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10 (494 aa) | |||
NCBP1 | nuclear cap binding protein subunit 1, 80kDa; Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5’-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5’-end of mRNA and to mRNA export in a 5’ to 3’ direction through the nuclear pore. T [...] (790 aa) | |||
HIST1H4F | histone cluster 1, H4f (103 aa) | |||
SRSF5 | serine/arginine-rich splicing factor 5; Plays a role in constitutive splicing and can modulate the selection of alternative splice sites (272 aa) | |||
HMGA2 | high mobility group AT-hook 2; Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes (By similarity) (109 aa) | |||
ELAVL1 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro (326 aa) | |||
C4orf27 | chromosome 4 open reading frame 27 (346 aa) | |||
LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae); Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs (463 aa) |