node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BAG3 | UBC | ENSP00000358081 | ENSP00000344818 | BCL2-associated athanogene 3; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity | ubiquitin C | 0.972 |
CDC37 | UBC | ENSP00000222005 | ENSP00000344818 | cell division cycle 37 homolog (S. cerevisiae); Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity | ubiquitin C | 0.992 |
DPCD | RUVBL1 | ENSP00000359170 | ENSP00000318297 | deleted in primary ciliary dyskinesia homolog (mouse); May play a role in the formation or function of ciliated cells | RuvB-like 1 (E. coli); May be able to bind plasminogen at cell surface and enhance plasminogen activation | 0.960 |
DPCD | RUVBL2 | ENSP00000359170 | ENSP00000473172 | deleted in primary ciliary dyskinesia homolog (mouse); May play a role in the formation or function of ciliated cells | RuvB-like 2 (E. coli); Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5’ to 3’) activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity | 0.957 |
RPAP3 | RUVBL1 | ENSP00000005386 | ENSP00000318297 | RNA polymerase II associated protein 3; Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation | RuvB-like 1 (E. coli); May be able to bind plasminogen at cell surface and enhance plasminogen activation | 0.992 |
RPAP3 | RUVBL2 | ENSP00000005386 | ENSP00000473172 | RNA polymerase II associated protein 3; Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation | RuvB-like 2 (E. coli); Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5’ to 3’) activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity | 0.993 |
RPAP3 | UBC | ENSP00000005386 | ENSP00000344818 | RNA polymerase II associated protein 3; Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation | ubiquitin C | 0.483 |
RUVBL1 | DPCD | ENSP00000318297 | ENSP00000359170 | RuvB-like 1 (E. coli); May be able to bind plasminogen at cell surface and enhance plasminogen activation | deleted in primary ciliary dyskinesia homolog (mouse); May play a role in the formation or function of ciliated cells | 0.960 |
RUVBL1 | RPAP3 | ENSP00000318297 | ENSP00000005386 | RuvB-like 1 (E. coli); May be able to bind plasminogen at cell surface and enhance plasminogen activation | RNA polymerase II associated protein 3; Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation | 0.992 |
RUVBL1 | RUVBL2 | ENSP00000318297 | ENSP00000473172 | RuvB-like 1 (E. coli); May be able to bind plasminogen at cell surface and enhance plasminogen activation | RuvB-like 2 (E. coli); Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5’ to 3’) activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity | 0.999 |
RUVBL1 | UBC | ENSP00000318297 | ENSP00000344818 | RuvB-like 1 (E. coli); May be able to bind plasminogen at cell surface and enhance plasminogen activation | ubiquitin C | 0.912 |
RUVBL2 | DPCD | ENSP00000473172 | ENSP00000359170 | RuvB-like 2 (E. coli); Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5’ to 3’) activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity | deleted in primary ciliary dyskinesia homolog (mouse); May play a role in the formation or function of ciliated cells | 0.957 |
RUVBL2 | RPAP3 | ENSP00000473172 | ENSP00000005386 | RuvB-like 2 (E. coli); Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5’ to 3’) activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity | RNA polymerase II associated protein 3; Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation | 0.993 |
RUVBL2 | RUVBL1 | ENSP00000473172 | ENSP00000318297 | RuvB-like 2 (E. coli); Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5’ to 3’) activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity | RuvB-like 1 (E. coli); May be able to bind plasminogen at cell surface and enhance plasminogen activation | 0.999 |
RUVBL2 | UBC | ENSP00000473172 | ENSP00000344818 | RuvB-like 2 (E. coli); Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5’ to 3’) activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity | ubiquitin C | 0.987 |
UBC | BAG3 | ENSP00000344818 | ENSP00000358081 | ubiquitin C | BCL2-associated athanogene 3; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity | 0.972 |
UBC | CDC37 | ENSP00000344818 | ENSP00000222005 | ubiquitin C | cell division cycle 37 homolog (S. cerevisiae); Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity | 0.992 |
UBC | RPAP3 | ENSP00000344818 | ENSP00000005386 | ubiquitin C | RNA polymerase II associated protein 3; Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation | 0.483 |
UBC | RUVBL1 | ENSP00000344818 | ENSP00000318297 | ubiquitin C | RuvB-like 1 (E. coli); May be able to bind plasminogen at cell surface and enhance plasminogen activation | 0.912 |
UBC | RUVBL2 | ENSP00000344818 | ENSP00000473172 | ubiquitin C | RuvB-like 2 (E. coli); Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5’ to 3’) activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity | 0.987 |