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LHX6 LHX6 ALX3 ALX3 LMO2 LMO2 ALX1 ALX1 OTP OTP DRGX DRGX PRRX1 PRRX1 ISL1 ISL1 GSC GSC ARX ARX RHOXF2B RHOXF2B LHX5 LHX5 SEBOX SEBOX LBX1 LBX1 GSC2 GSC2 LHX2 LHX2 LHX8 LHX8 RBL2 RBL2 LHX9 LHX9 LMX1B LMX1B LMO1 LMO1 HOPX HOPX DMBX1 DMBX1 RAX RAX RHOXF2 RHOXF2 OG12 OG12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
GSC2goosecoid homeobox 2; May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC (205 aa)
ISL1ISL LIM homeobox 1; Binds and regulates the promoters of the insulin, glucagon and somatostatin genes. Involved in the specificarion of motor neurons in cooperation with LHX3 and LDB1 (By similarity) (349 aa)
GSCgoosecoid homeobox; Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity) (257 aa)
PRRX1paired related homeobox 1; Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity) (245 aa)
LMO2LIM domain only 2 (rhombotin-like 1); Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state (227 aa)
LHX5LIM homeobox 5; Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system (402 aa)
RBL2retinoblastoma-like 2 (p130); Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 ’Lys-20’ trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferent [...] (1139 aa)
LHX8LIM homeobox 8; Transcription factor involved in differentiation of certain neurons and mesenchymal cells (By similarity) (356 aa)
OTPorthopedia homeobox; Probably involved in the differentiation of hypothalamic neuroendocrine cells (325 aa)
ALX1ALX homeobox 1; Transcriptional activator that acts at a palindromic recognition sequence to enhance the activity of the SV40 and TK promoters. Functions as a repressor with the prolactin promoter in vivo. May play a role in chondrocyte differentiation and may also influence cervix development (326 aa)
RAXretina and anterior neural fold homeobox; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter (346 aa)
LMO1LIM domain only 1 (rhombotin 1); May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors (156 aa)
LMX1BLIM homeobox transcription factor 1, beta; Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels (406 aa)
DMBX1diencephalon/mesencephalon homeobox 1; Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5’-TAATCCGATTA-3’) sequence. Required for brain development (By similarity) (377 aa)
LHX9LIM homeobox 9; Involved in gonadal development (By similarity) (397 aa)
ALX3ALX homeobox 3; Transcriptional regulator with a possible role in patterning of mesoderm during development (By similarity) (343 aa)
LBX1ladybird homeobox 1; Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord (By similarity) (281 aa)
RHOXF2Rhox homeobox family, member 2 (288 aa)
RHOXF2BRhox homeobox family, member 2B (288 aa)
LHX2LIM homeobox 2; Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity) (406 aa)
ARXaristaless related homeobox; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate (562 aa)
LHX6LIM homeobox 6 (392 aa)
DRGXdorsal root ganglia homeobox; Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain (By similarity) (268 aa)
SEBOXSEBOX homeobox; Probable transcription factor involved in the control of specification of mesoderm and endoderm (By similarity) (216 aa)
OG12short stature homeobox protein 2 isoform c ; May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation (319 aa)
HOPXHOP homeobox; Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor (112 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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