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PPP2CB | protein phosphatase 2, catalytic subunit, beta isozyme; PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase (309 aa) | |||
PPP2R5A | protein phosphatase 2, regulatory subunit B’, alpha; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment (486 aa) | |||
MEIS1 | Meis homeobox 1; Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias (390 aa) | |||
ISL2 | ISL LIM homeobox 2; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways (By similarity) (359 aa) | |||
PKNOX1 | PBX/knotted 1 homeobox 1 (436 aa) | |||
LHX8 | LIM homeobox 8; Transcription factor involved in differentiation of certain neurons and mesenchymal cells (By similarity) (356 aa) | |||
LMX1A | LIM homeobox transcription factor 1, alpha; Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity) (382 aa) | |||
PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during [...] (327 aa) | |||
LMO3 | LIM domain only 3 (rhombotin-like 2) (145 aa) | |||
SOX2 | SRY (sex determining region Y)-box 2; Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiat [...] (317 aa) | |||
PPP1CC | protein phosphatase 1, catalytic subunit, gamma isozyme; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- associated Ca [...] (323 aa) | |||
LMO1 | LIM domain only 1 (rhombotin 1); May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors (156 aa) | |||
LMX1B | LIM homeobox transcription factor 1, beta; Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels (406 aa) | |||
LHX9 | LIM homeobox 9; Involved in gonadal development (By similarity) (397 aa) | |||
EMX2 | empty spiracles homeobox 2; Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system (252 aa) | |||
TLX1 | T-cell leukemia homeobox 1; Controls the genesis of the spleen. Binds to the DNA sequence 5’-GGCGGTAAGTGG-3’ (330 aa) | |||
PBX3 | pre-B-cell leukemia homeobox 3; Transcriptional activator that binds the sequence 5’- ATCAATCAA-3’ (434 aa) | |||
LHX2 | LIM homeobox 2; Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity) (406 aa) | |||
PBX2 | pre-B-cell leukemia homeobox 2; Transcriptional activator that binds the sequence 5’- ATCAATCAA-3’. Activates transcription of PF4 in complex with MEIS1 (430 aa) | |||
TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG (770 aa) | |||
ARX | aristaless related homeobox; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate (562 aa) | |||
ETS1 | v-ets erythroblastosis virus E26 oncogene homolog 1 (avian); Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion (485 aa) | |||
PBX1 | pre-B-cell leukemia homeobox 1; Binds the sequence 5’-ATCAATCAA-3’. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1-PBX1b-MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...] (430 aa) | |||
PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at ’Ser-259’ (309 aa) | |||
MEIS2 | Meis homeobox 2 (477 aa) | |||
NFIC | nuclear factor I/C (CCAAT-binding transcription factor); Recognizes and binds the palindromic sequence 5’- TTGGCNNNNNGCCAA-3’ present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication (By similarity) (499 aa) |