Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 (509 aa) | ||
 | FDFT1 | farnesyl-diphosphate farnesyltransferase 1 (417 aa) | ||
 | TMEM30A | transmembrane protein 30A (361 aa) | ||
 | HSD17B7 | hydroxysteroid (17-beta) dehydrogenase 7; Responsible for the reduction of the keto group on the C-3 of sterols (341 aa) | ||
 | C14orf1 | chromosome 14 open reading frame 1 (140 aa) | ||
 | MSMO1 | methylsterol monooxygenase 1 (293 aa) | ||
 | SPTLC1 | serine palmitoyltransferase, long chain base subunit 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1- SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isoz [...] (473 aa) | ||
 | SC5DL | sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol (299 aa) | ||
 | SQLE | squalene epoxidase; Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway (574 aa) | ||
 | LBR | lamin B receptor; Anchors the lamina and the heterochromatin to the inner nuclear membrane (615 aa) | ||
 | EIF2B5 | eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa; Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP (721 aa) | ||
 | SIGMAR1 | sigma non-opioid intracellular receptor 1 (223 aa) | ||
 | TM7SF2 | transmembrane 7 superfamily member 2; Involved in the conversion of lanosterol to cholesterol (418 aa) | ||
 | GMPPB | GDP-mannose pyrophosphorylase B (387 aa) | ||
 | ALAS1 | aminolevulinate, delta-, synthase 1 (640 aa) | ||
 | UGDH | UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate (494 aa) | ||
 | C5orf4 | chromosome 5 open reading frame 4 (333 aa) | ||
 | ALAS2 | aminolevulinate, delta-, synthase 2 (587 aa) | ||
 | AGMO | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes (445 aa) | ||
 | LSS | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus (732 aa) | ||
 | NSDHL | NAD(P) dependent steroid dehydrogenase-like (373 aa) | ||
 | CH25H | cholesterol 25-hydroxylase; Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25- hydroxycholesterol by macrophages may play a role in Leydig cell differentiation (272 aa) | ||
 | GALE | UDP-galactose-4-epimerase; Catalyzes two distinct but analogous reactions- the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine (348 aa) | ||
 | GALT | galactose-1-phosphate uridylyltransferase (379 aa) | ||
 | GCAT | glycine C-acetyltransferase (445 aa) | ||
 | NDUFAF6 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6; Involved in the assembly of mitochondrial NADH-ubiquinone oxidoreductase complex (complex I) at early stages. May play a role in the biogenesis of MT-ND1 (333 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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