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TBC1D3G TBC1D3G TBC1D3 TBC1D3 USP6 USP6 RABEP2 RABEP2 TBC1D3C TBC1D3C RABEP1 RABEP1 ELAVL1 ELAVL1 AURKB AURKB CDCA8 CDCA8 BIRC5 BIRC5 RAB11B RAB11B INCENP INCENP RAB11A RAB11A RAB1B RAB1B PLK1 PLK1 EVI5 EVI5 FBXO5 FBXO5 RABGAP1L RABGAP1L TBC1D3H TBC1D3H USP6NL USP6NL RABGAP1 RABGAP1 TBC1D3B TBC1D3B TBC1D28 TBC1D28 TBC1D29 TBC1D29 TBC1D3F TBC1D3F TBC1D26 TBC1D26
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
FBXO5F-box protein 5; Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding (447 aa)
USP6ubiquitin specific peptidase 6 (Tre-2 oncogene); Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6- dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation (1406 aa)
RABGAP1LRAB GTPase activating protein 1-like (815 aa)
RAB11ARAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...] (216 aa)
RABEP1rabaptin, RAB GTPase binding effector protein 1; Rab effector protein acting as linker between gamma- adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A (862 aa)
USP6NLUSP6 N-terminal like; Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex (845 aa)
PLK1polo-like kinase 1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55 [...] (603 aa)
BIRC5baculoviral IAP repeat containing 5 (165 aa)
RAB1BRAB1B, member RAS oncogene family; Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments (201 aa)
CDCA8cell division cycle associated 8; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment (280 aa)
TBC1D3FTBC1 domain family, member 3F; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) (549 aa)
RAB11BRAB11B, member RAS oncogene family; GTPase that modulates endosomal trafficking. Acts as a major regulator of membrane delivery during cytokinesis (By similarity) (218 aa)
TBC1D28TBC1 domain family, member 28 (210 aa)
TBC1D3GTBC1 domain family, member 3G; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) (549 aa)
TBC1D3TBC1 domain family, member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (549 aa)
RABEP2rabaptin, RAB GTPase binding effector protein 2; Plays a role in membrane trafficking and in homotypic early endosome fusion (569 aa)
EVI5ecotropic viral integration site 5; Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis (810 aa)
RABGAP1RAB GTPase activating protein 1; May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase- anaphase transition (1069 aa)
INCENPinner centromere protein antigens 135/155kDa; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Probably acts through association with AURKB or AURKC. Seems to bind directly to microtubules. Controls the kinetochore localization of BUB1 (918 aa)
TBC1D3BTBC1 domain family, member 3B; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) (549 aa)
ELAVL1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro (326 aa)
TBC1D3CTBC1 domain family, member 3C; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) (549 aa)
TBC1D3HTBC1 domain family, member 3H; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) (549 aa)
TBC1D26TBC1 domain family, member 26; May act as a GTPase-activating protein for Rab family protein(s) (Potential) (250 aa)
TBC1D29TBC1 domain family, member 29 (150 aa)
AURKBaurora kinase B (344 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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