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HPS5 HPS5 BLOC1S4 BLOC1S4 HPS3 HPS3 OSBPL9 OSBPL9 HPS6 HPS6 HPS1 HPS1 BLOC1S3 BLOC1S3 DTNBP1 DTNBP1 BLOC1S5 BLOC1S5 HPS4 HPS4 IFT57 IFT57 SNAPIN SNAPIN BLOC1S6 BLOC1S6 BLOC1S1 BLOC1S1 BLOC1S2 BLOC1S2 TUBGCP4 TUBGCP4 MZT2A MZT2A TUBGCP6 TUBGCP6 WASH6P WASH6P TUBG1 TUBG1 MZT2B MZT2B TUBGCP5 TUBGCP5 TOPORS TOPORS MZT1 MZT1 BRCA1 BRCA1 CENPJ CENPJ
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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fusion edge
gene fusions
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gene co-occurrence
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textmining
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co-expression
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Your Input:
BLOC1S6biogenesis of lysosomal organelles complex-1, subunit 6, pallidin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, partic [...] (172 aa)
TUBGCP6tubulin, gamma complex associated protein 6; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome (1819 aa)
TUBG1tubulin, gamma 1; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (451 aa)
IFT57intraflagellar transport 57 homolog (Chlamydomonas); Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5’-AAAGACATG-3’ present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear (429 aa)
HPS5Hermansky-Pudlak syndrome 5; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins (1129 aa)
MZT2Bmitotic spindle organizing protein 2B (158 aa)
TUBGCP5tubulin, gamma complex associated protein 5; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome (1024 aa)
HPS3Hermansky-Pudlak syndrome 3; Involved in early stages of melanosome biogenesis and maturation (By similarity) (1004 aa)
HPS6Hermansky-Pudlak syndrome 6; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules (775 aa)
MZT2Amitotic spindle organizing protein 2A (158 aa)
BLOC1S4biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking (217 aa)
HPS1Hermansky-Pudlak syndrome 1; Component of multiple cytoplasmic organelles. Apparently crucial for their normal development and function. May be involved in intracellular protein sorting (700 aa)
HPS4Hermansky-Pudlak syndrome 4; May function in the pathway of organelle biogenesis (708 aa)
DTNBP1dystrobrevin binding protein 1; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 fun [...] (351 aa)
WASH6PWAS protein family homolog 6 pseudogene; Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (By similarity) (478 aa)
TOPORStopoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase; Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage- induced cell death through IKBKE sumoylation (1045 aa)
SNAPINSNAP-associated protein; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. May modulate a step between vesicle priming, fusion [...] (136 aa)
BLOC1S2biogenesis of lysosomal organelles complex-1, subunit 2; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. May play a role in [...] (142 aa)
MZT1mitotic spindle organizing protein 1; Required for gamma-tubulin complex recruitment to the centrosome (82 aa)
CENPJcentromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome (1338 aa)
BLOC1S5biogenesis of lysosomal organelles complex-1, subunit 5, muted; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking (187 aa)
BLOC1S3biogenesis of lysosomal organelles complex-1, subunit 3; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking (202 aa)
OSBPL9oxysterol binding protein-like 9 (746 aa)
BRCA1breast cancer 1, early onset; E3 ubiquitin-protein ligase that specifically mediates the formation of ’Lys-6’-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Reg [...] (1884 aa)
BLOC1S1biogenesis of lysosomal organelles complex-1, subunit 1; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May negatively regulate aerobic respiration through mitochondrial prot [...] (153 aa)
TUBGCP4tubulin, gamma complex associated protein 4; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome (666 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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