node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARX | LHX1 | ENSP00000368332 | ENSP00000254457 | aristaless related homeobox; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate | LIM homeobox 1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis | 0.595 |
ARX | LHX5 | ENSP00000368332 | ENSP00000261731 | aristaless related homeobox; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate | LIM homeobox 5; Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system | 0.596 |
BARHL2 | LHX1 | ENSP00000359474 | ENSP00000254457 | BarH-like homeobox 2; Potential regulator of neural basic helix-loop-helix genes (By similarity) | LIM homeobox 1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis | 0.403 |
BARHL2 | LHX2 | ENSP00000359474 | ENSP00000362717 | BarH-like homeobox 2; Potential regulator of neural basic helix-loop-helix genes (By similarity) | LIM homeobox 2; Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity) | 0.866 |
ISL1 | LHX1 | ENSP00000230658 | ENSP00000254457 | ISL LIM homeobox 1; Binds and regulates the promoters of the insulin, glucagon and somatostatin genes. Involved in the specificarion of motor neurons in cooperation with LHX3 and LDB1 (By similarity) | LIM homeobox 1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis | 0.635 |
ISL1 | NOTCH1 | ENSP00000230658 | ENSP00000277541 | ISL LIM homeobox 1; Binds and regulates the promoters of the insulin, glucagon and somatostatin genes. Involved in the specificarion of motor neurons in cooperation with LHX3 and LDB1 (By similarity) | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | 0.578 |
LHX1 | ARX | ENSP00000254457 | ENSP00000368332 | LIM homeobox 1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis | aristaless related homeobox; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate | 0.595 |
LHX1 | BARHL2 | ENSP00000254457 | ENSP00000359474 | LIM homeobox 1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis | BarH-like homeobox 2; Potential regulator of neural basic helix-loop-helix genes (By similarity) | 0.403 |
LHX1 | ISL1 | ENSP00000254457 | ENSP00000230658 | LIM homeobox 1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis | ISL LIM homeobox 1; Binds and regulates the promoters of the insulin, glucagon and somatostatin genes. Involved in the specificarion of motor neurons in cooperation with LHX3 and LDB1 (By similarity) | 0.635 |
LHX2 | BARHL2 | ENSP00000362717 | ENSP00000359474 | LIM homeobox 2; Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity) | BarH-like homeobox 2; Potential regulator of neural basic helix-loop-helix genes (By similarity) | 0.866 |
LHX2 | LMO1 | ENSP00000362717 | ENSP00000338207 | LIM homeobox 2; Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity) | LIM domain only 1 (rhombotin 1); May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors | 0.746 |
LHX2 | LMO3 | ENSP00000362717 | ENSP00000312856 | LIM homeobox 2; Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity) | LIM domain only 3 (rhombotin-like 2) | 0.757 |
LHX2 | NOTCH1 | ENSP00000362717 | ENSP00000277541 | LIM homeobox 2; Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity) | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | 0.607 |
LHX2 | WNT8B | ENSP00000362717 | ENSP00000340677 | LIM homeobox 2; Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity) | wingless-type MMTV integration site family, member 8B; Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus | 0.470 |
LHX5 | ARX | ENSP00000261731 | ENSP00000368332 | LIM homeobox 5; Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system | aristaless related homeobox; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate | 0.596 |
LHX5 | WNT8B | ENSP00000261731 | ENSP00000340677 | LIM homeobox 5; Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system | wingless-type MMTV integration site family, member 8B; Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus | 0.454 |
LHX9 | LMO1 | ENSP00000356357 | ENSP00000338207 | LIM homeobox 9; Involved in gonadal development (By similarity) | LIM domain only 1 (rhombotin 1); May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors | 0.743 |
LHX9 | LMO3 | ENSP00000356357 | ENSP00000312856 | LIM homeobox 9; Involved in gonadal development (By similarity) | LIM domain only 3 (rhombotin-like 2) | 0.755 |
LHX9 | NOTCH1 | ENSP00000356357 | ENSP00000277541 | LIM homeobox 9; Involved in gonadal development (By similarity) | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | 0.517 |
LMO1 | LHX2 | ENSP00000338207 | ENSP00000362717 | LIM domain only 1 (rhombotin 1); May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors | LIM homeobox 2; Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity) | 0.746 |