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TRIM45 TRIM45 HLA-F HLA-F TRIM26 TRIM26 FCGR1B FCGR1B IRF1 IRF1 GBP6 GBP6 HLA-A HLA-A FCGR1A FCGR1A TRIM17 TRIM17 TRIM10 TRIM10 PTAFR PTAFR OAS1 OAS1 IRF9 IRF9 PML PML OAS3 OAS3 CIITA CIITA IRF8 IRF8 TRIM2 TRIM2 TRIM35 TRIM35 TRIM38 TRIM38 TRIM22 TRIM22 TRIM29 TRIM29 TRIM3 TRIM3 TRIM21 TRIM21 HLA-E HLA-E TRIM6 TRIM6
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
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gene co-occurrence
Others
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textmining
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co-expression
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Your Input:
OAS32’-5’-oligoadenylate synthetase 3, 100kDa; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2’-5’- oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in [...] (1087 aa)
TRIM38tripartite motif containing 38 (465 aa)
IRF1interferon regulatory factor 1; Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target [...] (325 aa)
TRIM21tripartite motif containing 21; E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)- like complex is shown to mediate ubiquitination of CDKN1B (’Thr- 187’ phosphorylated-form), thereby promoting its degradat [...] (475 aa)
TRIM45tripartite motif containing 45; May act as a transcriptional repressor in mitogen- activated protein kinase signaling pathway (580 aa)
HLA-Fmajor histocompatibility complex, class I, F (442 aa)
PMLpromyelocytic leukemia (882 aa)
IRF8interferon regulatory factor 8; Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5’-TGAnTCA/GAAA-3’), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity) (426 aa)
TRIM17tripartite motif containing 17; May function as an ubiquitin E3 ligase (477 aa)
TRIM35tripartite motif containing 35; May play a role as a tumor suppressor. Implicated in the cell death mechanism (By similarity) (493 aa)
PTAFRplatelet-activating factor receptor; Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol- calcium second messenger system (342 aa)
CIITAclass II, major histocompatibility complex, transactivator; Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter (1130 aa)
TRIM2tripartite motif containing 2; UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11 (By similarity). Plays a neuroprotective function (By similarity). May play a role in neuronal rapid ischemic tolerance (By similarity) (771 aa)
TRIM3tripartite motif containing 3; Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (744 aa)
TRIM29tripartite motif containing 29; It is able to complement the radiosensitivity defect of an ataxia telangiectasia (AT) fibroblast cell line (588 aa)
FCGR1AFc fragment of IgG, high affinity Ia, receptor (CD64) (374 aa)
FCGR1BFc fragment of IgG, high affinity Ib, receptor (CD64); May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function in the humoral immune response (280 aa)
GBP6guanylate binding protein family, member 6; Binds GTP, GDP and GMP (By similarity) (633 aa)
HLA-Emajor histocompatibility complex, class I, E (358 aa)
HLA-Amajor histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity) (365 aa)
TRIM22tripartite motif containing 22; Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity (498 aa)
TRIM6tripartite motif containing 6 (516 aa)
IRF9interferon regulatory factor 9; Transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (393 aa)
OAS12’-5’-oligoadenylate synthetase 1, 40/46kDa (414 aa)
TRIM26tripartite motif containing 26 (539 aa)
TRIM10tripartite motif containing 10 (481 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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