node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACACA | ACACB | ENSP00000344789 | ENSP00000341044 | acetyl-CoA carboxylase alpha | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | 0.999 |
ACACA | UBC | ENSP00000344789 | ENSP00000344818 | acetyl-CoA carboxylase alpha | ubiquitin C | 0.922 |
ACACB | ACACA | ENSP00000341044 | ENSP00000344789 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | acetyl-CoA carboxylase alpha | 0.999 |
ACACB | UBC | ENSP00000341044 | ENSP00000344818 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | ubiquitin C | 0.851 |
ATL1 | GBP3 | ENSP00000351155 | ENSP00000359512 | atlastin GTPase 1; GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development | guanylate binding protein 3 | 0.592 |
ATL1 | UBC | ENSP00000351155 | ENSP00000344818 | atlastin GTPase 1; GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development | ubiquitin C | 0.620 |
GBP3 | ATL1 | ENSP00000359512 | ENSP00000351155 | guanylate binding protein 3 | atlastin GTPase 1; GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development | 0.592 |
GBP3 | MAP4K4 | ENSP00000359512 | ENSP00000314363 | guanylate binding protein 3 | mitogen-activated protein kinase kinase kinase kinase 4; Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322 | 0.648 |
GBP3 | NFATC2 | ENSP00000359512 | ENSP00000379330 | guanylate binding protein 3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.900 |
IRF7 | UBC | ENSP00000329411 | ENSP00000344818 | interferon regulatory factor 7; Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88- independent pathway and the TLR-activated, MyD88-dependent [...] | ubiquitin C | 0.999 |
MAP4K4 | GBP3 | ENSP00000314363 | ENSP00000359512 | mitogen-activated protein kinase kinase kinase kinase 4; Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322 | guanylate binding protein 3 | 0.648 |
MAP4K4 | UBC | ENSP00000314363 | ENSP00000344818 | mitogen-activated protein kinase kinase kinase kinase 4; Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322 | ubiquitin C | 0.999 |
NFATC2 | GBP3 | ENSP00000379330 | ENSP00000359512 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | guanylate binding protein 3 | 0.900 |
NFATC2 | UBC | ENSP00000379330 | ENSP00000344818 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | ubiquitin C | 0.576 |
UBC | ACACA | ENSP00000344818 | ENSP00000344789 | ubiquitin C | acetyl-CoA carboxylase alpha | 0.922 |
UBC | ACACB | ENSP00000344818 | ENSP00000341044 | ubiquitin C | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | 0.851 |
UBC | ATL1 | ENSP00000344818 | ENSP00000351155 | ubiquitin C | atlastin GTPase 1; GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development | 0.620 |
UBC | IRF7 | ENSP00000344818 | ENSP00000329411 | ubiquitin C | interferon regulatory factor 7; Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88- independent pathway and the TLR-activated, MyD88-dependent [...] | 0.999 |
UBC | MAP4K4 | ENSP00000344818 | ENSP00000314363 | ubiquitin C | mitogen-activated protein kinase kinase kinase kinase 4; Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322 | 0.999 |
UBC | NFATC2 | ENSP00000344818 | ENSP00000379330 | ubiquitin C | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.576 |