node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATF2 | COL24A1 | ENSP00000264110 | ENSP00000359603 | activating transcription factor 2; Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus- 5’- GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2/JUN complex | collagen, type XXIV, alpha 1; May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development | 0.905 |
COL12A1 | COL13A1 | ENSP00000325146 | ENSP00000381949 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | collagen, type XIII, alpha 1 | 0.918 |
COL12A1 | COL16A1 | ENSP00000325146 | ENSP00000362776 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | collagen, type XVI, alpha 1; Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations in cell morphology | 0.915 |
COL12A1 | COL17A1 | ENSP00000325146 | ENSP00000340937 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | collagen, type XVII, alpha 1; May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane | 0.921 |
COL12A1 | COL18A1 | ENSP00000325146 | ENSP00000347665 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | collagen, type XVIII, alpha 1 | 0.933 |
COL12A1 | COL1A1 | ENSP00000325146 | ENSP00000225964 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | collagen, type I, alpha 1 | 0.948 |
COL12A1 | COL1A2 | ENSP00000325146 | ENSP00000297268 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | collagen, type I, alpha 2 | 0.944 |
COL12A1 | COL24A1 | ENSP00000325146 | ENSP00000359603 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | collagen, type XXIV, alpha 1; May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development | 0.931 |
COL12A1 | COL27A1 | ENSP00000325146 | ENSP00000348385 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | collagen, type XXVII, alpha 1; Plays a role during the calcification of cartilage and the transition of cartilage to bone | 0.906 |
COL12A1 | COL2A1 | ENSP00000325146 | ENSP00000369889 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | collagen, type II, alpha 1 | 0.918 |
COL12A1 | COL3A1 | ENSP00000325146 | ENSP00000304408 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | collagen, type III, alpha 1 | 0.948 |
COL12A1 | COL4A1 | ENSP00000325146 | ENSP00000364979 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | collagen, type IV, alpha 1; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | 0.938 |
COL12A1 | COL4A2 | ENSP00000325146 | ENSP00000353654 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | collagen, type IV, alpha 2; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | 0.935 |
COL12A1 | COL4A3 | ENSP00000325146 | ENSP00000379823 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | collagen, type IV, alpha 3 (Goodpasture antigen) | 0.901 |
COL12A1 | COL4A4 | ENSP00000325146 | ENSP00000379866 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | collagen, type IV, alpha 4; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | 0.900 |
COL12A1 | COL5A2 | ENSP00000325146 | ENSP00000364000 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | collagen, type V, alpha 2 | 0.944 |
COL12A1 | COL5A3 | ENSP00000325146 | ENSP00000264828 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | collagen, type V, alpha 3; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin | 0.933 |
COL12A1 | COL6A1 | ENSP00000325146 | ENSP00000355180 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | collagen, type VI, alpha 1; Collagen VI acts as a cell-binding protein | 0.926 |
COL12A1 | COL6A2 | ENSP00000325146 | ENSP00000300527 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | collagen, type VI, alpha 2 | 0.914 |
COL12A1 | COL6A3 | ENSP00000325146 | ENSP00000295550 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | collagen, type VI, alpha 3; Collagen VI acts as a cell-binding protein | 0.918 |