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ENSG00000255168 ENSG00000255168 HMCN2 HMCN2 HGFAC HGFAC VWCE VWCE CFC1B CFC1B DLL4 DLL4 SCUBE3 SCUBE3 NOTCH2NL NOTCH2NL FBLN1 FBLN1 FBLN2 FBLN2 JAG1 JAG1 LTBP1 LTBP1 SLC9A6 SLC9A6 DLL3 DLL3 CRB2 CRB2 CFC1 CFC1 TDGF1 TDGF1 CFTR CFTR F12 F12 EGFL7 EGFL7 HABP2 HABP2 SNED1 SNED1 DLK1 DLK1 VWA1 VWA1 EYS EYS SLC9A7 SLC9A7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (1480 aa)
DLL3delta-like 3 (Drosophila); Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity) (618 aa)
DLL4delta-like 4 (Drosophila); Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4 (By similarity) (685 aa)
F12coagulation factor XII (Hageman factor); Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta- factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (615 aa)
JAG1jagged 1; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro) (1218 aa)
CFC1cripto, FRL-1, cryptic family 1; NODAL coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm and/or neural patterning during gastrulation (223 aa)
SCUBE3signal peptide, CUB domain, EGF-like 3; Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression (993 aa)
HABP2hyaluronan binding protein 2; Cleaves the alpha-chain at multiple sites and the beta- chain between ’Lys-53’ and ’Lys-54’ but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro- urokinase) to the active two chain form. Activates coagulation factor VII (560 aa)
CFC1Bcripto, FRL-1, cryptic family 1B (223 aa)
TDGF1teratocarcinoma-derived growth factor 1; Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. Activates the Nodal-dependent signaling pathway (188 aa)
EGFL7EGF-like-domain, multiple 7; Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cells adhesion to the substrate in vitro (By similarity) (273 aa)
SNED1sushi, nidogen and EGF-like domains 1 (1413 aa)
SLC9A7solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7; Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to Golgi volume and cation homeostasis (725 aa)
FBLN1fibulin 1 (703 aa)
VWCEvon Willebrand factor C and EGF domains; May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma (955 aa)
DLK1delta-like 1 homolog (Drosophila); May have a role in neuroendocrine differentiation (383 aa)
NOTCH2NLnotch 2 N-terminal like; May function in the Notch signaling pathway and regulate neutrophil differentiation (236 aa)
SLC9A6solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 (701 aa)
CRB2crumbs homolog 2 (Drosophila); May play a role in polarized cells morphogenesis (1285 aa)
HGFACHGF activator; Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form (655 aa)
FBLN2fibulin 2; Its binding to fibronectin and some other ligands is calcium dependent (1231 aa)
LTBP1latent transforming growth factor beta binding protein 1; May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM) (1721 aa)
HMCN2hemicentin 2 (789 aa)
VWA1von Willebrand factor A domain containing 1; Promotes matrix assembly (By similarity) (445 aa)
EYSeyes shut homolog (Drosophila) (3144 aa)
ENSG00000255168Uncharacterized protein (238 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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