Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
KLK15 KLK15 KLK8 KLK8 ELTD1 ELTD1 CFD CFD F12 F12 CMA1 CMA1 TNC TNC TNR TNR TPSG1 TPSG1 GZMM GZMM PRSS3 PRSS3 PAMR1 PAMR1 CTRC CTRC ACR ACR C1R C1R TENM2 TENM2 PLAT PLAT CFI CFI GZMK GZMK TENM1 TENM1 TNN TNN FLRT1 FLRT1 PRSS27 PRSS27 FLRT3 FLRT3 KLK5 KLK5 TENM3 TENM3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
ACRacrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome (421 aa)
PLATplasminogen activator, tissue (562 aa)
GZMKgranzyme K (granzyme 3; tryptase II) (264 aa)
TPSG1tryptase gamma 1 (321 aa)
TNNtenascin N; Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity) (1299 aa)
FLRT1fibronectin leucine rich transmembrane protein 1; May have a function in cell adhesion and/or receptor signaling (674 aa)
CMA1chymase 1, mast cell; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion (247 aa)
F12coagulation factor XII (Hageman factor); Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta- factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (615 aa)
TNRtenascin R; Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repuls [...] (1358 aa)
GZMMgranzyme M (lymphocyte met-ase 1); Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha- tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells (257 aa)
TNCtenascin C; Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6 (2201 aa)
PAMR1peptidase domain containing associated with muscle regeneration 1; May play a role in regeneration of skeletal muscle (By similarity) (737 aa)
C1Rcomplement component 1, r subcomponent (668 aa)
PRSS27protease, serine 27 (290 aa)
CFDcomplement factor D (adipsin); Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway (253 aa)
KLK5kallikrein-related peptidase 5; May be involved in desquamation (293 aa)
FLRT3fibronectin leucine rich transmembrane protein 3; May have a function in cell adhesion and/or receptor signaling (649 aa)
PRSS3protease, serine, 3; Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5 (304 aa)
ELTD1EGF, latrophilin and seven transmembrane domain containing 1; Could be involved in cardiac development (690 aa)
CTRCchymotrypsin C (caldecrin); Has chymotrypsin-type protease activity and hypocalcemic activity (268 aa)
KLK8kallikrein-related peptidase 8 (305 aa)
CFIcomplement factor I; Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively (583 aa)
TENM3teneurin transmembrane protein 3; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes axon guidance and homophilic cell adhesion. Plays a role in the development of the visual pathway; regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. May function as a cellular signal transducer (By sim [...] (2699 aa)
TENM1teneurin transmembrane protein 1; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity) (2732 aa)
TENM2teneurin transmembrane protein 2; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion (By similarity). May function as a cellular signal transducer (2774 aa)
KLK15kallikrein-related peptidase 15; Protease whose physiological substrate is not yet known (256 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (38%)