26 items (Homo sapiens) - STRING network view

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	DIMT1	DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae); Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3’-end of 18S rRNA in the 40S particle (By similarity) (313 aa)
	FBL	fibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (321 aa)
	RBM28	RNA binding motif protein 28; Nucleolar component of the spliceosomal ribonucleoprotein complexes (759 aa)
	BYSL	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos (437 aa)
	MPHOSPH10	M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein); Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (681 aa)
	NAT10	N-acetyltransferase 10 (GCN5-related); Has protein acetyltransferase activity in vitro. Can acetylate both histones and microtubules. Histone acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule stability and cell division (1025 aa)
	UTP20	UTP20, small subunit (SSU) processome component, homolog (yeast); Involved in 18S pre-rRNA processing. Associates with U3 snoRNA (2785 aa)
	DDX18	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Probable RNA-dependent helicase (670 aa)
	PNO1	partner of NOB1 homolog (S. cerevisiae) (252 aa)
	NOP58	NOP58 ribonucleoprotein homolog (yeast); Required for 60S ribosomal subunit biogenesis (By similarity) (529 aa)
	MKI67IP	MKI67 (FHA domain) interacting nucleolar phosphoprotein (293 aa)
	UTP15	UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae); Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity) (518 aa)
	TSR1	TSR1, 20S rRNA accumulation, homolog (S. cerevisiae); Required during maturation of the 40S ribosomal subunit in the nucleolus (By similarity) (804 aa)
	DHX37	DEAH (Asp-Glu-Ala-His) box polypeptide 37 (1157 aa)
	DDX10	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10; Putative ATP-dependent RNA helicase (875 aa)
	NOC4L	nucleolar complex associated 4 homolog (S. cerevisiae) (516 aa)
	H1FX	H1 histone family, member X; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures (213 aa)
	HEATR1	HEAT repeat containing 1; Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity) (2144 aa)
	DKC1	dyskeratosis congenita 1, dyskerin; Isoform 1- Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (’psi’) residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomera [...] (514 aa)
	PDCD11	programmed cell death 11; Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA (1871 aa)
	RPL5	ribosomal protein L5; Required for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA (297 aa)
	RRP12	ribosomal RNA processing 12 homolog (S. cerevisiae) (1297 aa)
	NOC3L	nucleolar complex associated 3 homolog (S. cerevisiae); May be required for adipogenesis (By similarity) (800 aa)
	POLR3F	polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcript [...] (316 aa)
	NOP56	NOP56 ribonucleoprotein homolog (yeast); Involved in the early to middle stages of 60S ribosomal subunit biogenesis (594 aa)
	RSL1D1	ribosomal L1 domain containing 1 (490 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BYSL	DDX10	ENSP00000230340	ENSP00000314348	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10; Putative ATP-dependent RNA helicase	0.878
BYSL	DDX18	ENSP00000230340	ENSP00000263239	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Probable RNA-dependent helicase	0.885
BYSL	DHX37	ENSP00000230340	ENSP00000311135	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	DEAH (Asp-Glu-Ala-His) box polypeptide 37	0.991
BYSL	DIMT1	ENSP00000230340	ENSP00000199320	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae); Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3’-end of 18S rRNA in the 40S particle (By similarity)	0.995
BYSL	DKC1	ENSP00000230340	ENSP00000358563	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	dyskeratosis congenita 1, dyskerin; Isoform 1- Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (’psi’) residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomera [...]	0.748
BYSL	FBL	ENSP00000230340	ENSP00000221801	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	fibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	0.990
BYSL	HEATR1	ENSP00000230340	ENSP00000355541	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	HEAT repeat containing 1; Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity)	0.976
BYSL	MKI67IP	ENSP00000230340	ENSP00000285814	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	MKI67 (FHA domain) interacting nucleolar phosphoprotein	0.968
BYSL	MPHOSPH10	ENSP00000230340	ENSP00000244230	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein); Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing	0.988
BYSL	NAT10	ENSP00000230340	ENSP00000257829	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	N-acetyltransferase 10 (GCN5-related); Has protein acetyltransferase activity in vitro. Can acetylate both histones and microtubules. Histone acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule stability and cell division	0.995
BYSL	NOC3L	ENSP00000230340	ENSP00000360412	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	nucleolar complex associated 3 homolog (S. cerevisiae); May be required for adipogenesis (By similarity)	0.850
BYSL	NOC4L	ENSP00000230340	ENSP00000328854	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	nucleolar complex associated 4 homolog (S. cerevisiae)	0.997
BYSL	NOP56	ENSP00000230340	ENSP00000370589	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	NOP56 ribonucleoprotein homolog (yeast); Involved in the early to middle stages of 60S ribosomal subunit biogenesis	0.976
BYSL	NOP58	ENSP00000230340	ENSP00000264279	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	NOP58 ribonucleoprotein homolog (yeast); Required for 60S ribosomal subunit biogenesis (By similarity)	0.977
BYSL	PDCD11	ENSP00000230340	ENSP00000358812	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	programmed cell death 11; Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA	0.944
BYSL	PNO1	ENSP00000230340	ENSP00000263657	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	partner of NOB1 homolog (S. cerevisiae)	0.999
BYSL	RBM28	ENSP00000230340	ENSP00000223073	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	RNA binding motif protein 28; Nucleolar component of the spliceosomal ribonucleoprotein complexes	0.908
BYSL	RPL5	ENSP00000230340	ENSP00000359345	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	ribosomal protein L5; Required for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA	0.573
BYSL	RRP12	ENSP00000230340	ENSP00000360031	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	ribosomal RNA processing 12 homolog (S. cerevisiae)	0.998
BYSL	RSL1D1	ENSP00000230340	ENSP00000460871	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	ribosomal L1 domain containing 1	0.807

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