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SCAP | SREBF chaperone; Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the [...] (1279 aa) | |||
CCT8L2 | chaperonin containing TCP1, subunit 8 (theta)-like 2; Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis (By similarity) (557 aa) | |||
DCAF12L1 | DDB1 and CUL4 associated factor 12-like 1 (463 aa) | |||
SH2D2A | SH2 domain containing 2A; Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56- LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation (399 aa) |