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BNIP3L BNIP3L BNIP3 BNIP3 TMEM218 TMEM218 TMEM190 TMEM190 OLFM4 OLFM4 SLC1A1 SLC1A1 PLN PLN GIMAP5 GIMAP5 LDLRAD1 LDLRAD1 TMEM147 TMEM147 GPR128 GPR128 LAPTM5 LAPTM5 MALL MALL PTTG1IP PTTG1IP VTI1B VTI1B MARCH2 MARCH2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
MARCH2membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6 (246 aa)
OLFM4olfactomedin 4; May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin (510 aa)
TMEM147transmembrane protein 147 (224 aa)
SLC1A1solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity) (524 aa)
MALLmal, T-cell differentiation protein-like (153 aa)
GPR128G protein-coupled receptor 128; Orphan receptor (797 aa)
TMEM218transmembrane protein 218 (115 aa)
TMEM190transmembrane protein 190 (177 aa)
LAPTM5lysosomal protein transmembrane 5; May have a special functional role during embryogenesis and in adult hematopoietic cells (262 aa)
PTTG1IPpituitary tumor-transforming 1 interacting protein; May facilitate PTTG1 nuclear translocation (180 aa)
PLNphospholamban; Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum (52 aa)
GIMAP5GTPase, IMAP family member 5; Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence (By similarity) (307 aa)
BNIP3BCL2/adenovirus E1B 19kDa interacting protein 3; Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP- in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane [...] (194 aa)
LDLRAD1low density lipoprotein receptor class A domain containing 1 (205 aa)
BNIP3LBCL2/adenovirus E1B 19kDa interacting protein 3-like; Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP- in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 [...] (219 aa)
VTI1Bvesicle transport through interaction with t-SNAREs homolog 1B (yeast); V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence (232 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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