node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BNIP3 | BNIP3L | ENSP00000357625 | ENSP00000370003 | BCL2/adenovirus E1B 19kDa interacting protein 3; Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP- in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane [...] | BCL2/adenovirus E1B 19kDa interacting protein 3-like; Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP- in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 [...] | 0.980 |
BNIP3 | LDLRAD1 | ENSP00000357625 | ENSP00000360411 | BCL2/adenovirus E1B 19kDa interacting protein 3; Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP- in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane [...] | low density lipoprotein receptor class A domain containing 1 | 0.495 |
BNIP3L | BNIP3 | ENSP00000370003 | ENSP00000357625 | BCL2/adenovirus E1B 19kDa interacting protein 3-like; Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP- in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 [...] | BCL2/adenovirus E1B 19kDa interacting protein 3; Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP- in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane [...] | 0.980 |
BNIP3L | LDLRAD1 | ENSP00000370003 | ENSP00000360411 | BCL2/adenovirus E1B 19kDa interacting protein 3-like; Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP- in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 [...] | low density lipoprotein receptor class A domain containing 1 | 0.495 |
GIMAP5 | LDLRAD1 | ENSP00000351473 | ENSP00000360411 | GTPase, IMAP family member 5; Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence (By similarity) | low density lipoprotein receptor class A domain containing 1 | 0.475 |
GPR128 | LDLRAD1 | ENSP00000273352 | ENSP00000360411 | G protein-coupled receptor 128; Orphan receptor | low density lipoprotein receptor class A domain containing 1 | 0.537 |
LAPTM5 | LDLRAD1 | ENSP00000294507 | ENSP00000360411 | lysosomal protein transmembrane 5; May have a special functional role during embryogenesis and in adult hematopoietic cells | low density lipoprotein receptor class A domain containing 1 | 0.537 |
LDLRAD1 | BNIP3 | ENSP00000360411 | ENSP00000357625 | low density lipoprotein receptor class A domain containing 1 | BCL2/adenovirus E1B 19kDa interacting protein 3; Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP- in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane [...] | 0.495 |
LDLRAD1 | BNIP3L | ENSP00000360411 | ENSP00000370003 | low density lipoprotein receptor class A domain containing 1 | BCL2/adenovirus E1B 19kDa interacting protein 3-like; Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP- in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 [...] | 0.495 |
LDLRAD1 | GIMAP5 | ENSP00000360411 | ENSP00000351473 | low density lipoprotein receptor class A domain containing 1 | GTPase, IMAP family member 5; Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence (By similarity) | 0.475 |
LDLRAD1 | GPR128 | ENSP00000360411 | ENSP00000273352 | low density lipoprotein receptor class A domain containing 1 | G protein-coupled receptor 128; Orphan receptor | 0.537 |
LDLRAD1 | LAPTM5 | ENSP00000360411 | ENSP00000294507 | low density lipoprotein receptor class A domain containing 1 | lysosomal protein transmembrane 5; May have a special functional role during embryogenesis and in adult hematopoietic cells | 0.537 |
LDLRAD1 | MARCH2 | ENSP00000360411 | ENSP00000215555 | low density lipoprotein receptor class A domain containing 1 | membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6 | 0.475 |
LDLRAD1 | PLN | ENSP00000360411 | ENSP00000350132 | low density lipoprotein receptor class A domain containing 1 | phospholamban; Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum | 0.692 |
LDLRAD1 | PTTG1IP | ENSP00000360411 | ENSP00000328325 | low density lipoprotein receptor class A domain containing 1 | pituitary tumor-transforming 1 interacting protein; May facilitate PTTG1 nuclear translocation | 0.537 |
LDLRAD1 | SLC1A1 | ENSP00000360411 | ENSP00000262352 | low density lipoprotein receptor class A domain containing 1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity) | 0.537 |
MARCH2 | LDLRAD1 | ENSP00000215555 | ENSP00000360411 | membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6 | low density lipoprotein receptor class A domain containing 1 | 0.475 |
PLN | LDLRAD1 | ENSP00000350132 | ENSP00000360411 | phospholamban; Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum | low density lipoprotein receptor class A domain containing 1 | 0.692 |
PTTG1IP | LDLRAD1 | ENSP00000328325 | ENSP00000360411 | pituitary tumor-transforming 1 interacting protein; May facilitate PTTG1 nuclear translocation | low density lipoprotein receptor class A domain containing 1 | 0.537 |
SLC1A1 | LDLRAD1 | ENSP00000262352 | ENSP00000360411 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity) | low density lipoprotein receptor class A domain containing 1 | 0.537 |