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CBX1 | chromobox homolog 1; Component of heterochromatin. Recognizes and binds histone H3 tails methylated at ’Lys-9’, leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane (185 aa) | |||
CCNI | cyclin I (377 aa) | |||
ANK1 | ankyrin 1, erythrocytic (1897 aa) | |||
TM4SF20 | transmembrane 4 L six family member 20 (229 aa) | |||
TSPAN5 | tetraspanin 5 (268 aa) | |||
USP17L2 | ubiquitin specific peptidase 17-like family member 2; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of hist [...] (530 aa) | |||
C11orf30 | chromosome 11 open reading frame 30; Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (1322 aa) | |||
RTN4 | reticulon 4 (1192 aa) | |||
SP100 | SP100 nuclear antigen (885 aa) | |||
CHAMP1 | chromosome alignment maintaining phosphoprotein 1; Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore (812 aa) | |||
FAM210B | family with sequence similarity 210, member B (192 aa) | |||
MAU2 | MAU2 chromatid cohesion factor homolog (C. elegans); Required for association of the cohesin complex with chromatin during interphase. Plays a role in sister chromatid cohesion and normal progression through prometaphase (613 aa) | |||
BAP1 | BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase); Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at ’Lys-119’ (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward ’Lys-48’- linked polyubiquitin chains compared to ’Lys-63’-li [...] (729 aa) | |||
H2AFY | H2A histone family, member Y; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactiv [...] (372 aa) |