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STRINGSTRING
CHERP CHERP NKAP NKAP PRPF40A PRPF40A SRA1 SRA1 CCDC155 CCDC155 U2AF1 U2AF1 TTC14 TTC14 ZCCHC10 ZCCHC10 TRIM41 TRIM41 MFAP1 MFAP1 UBC UBC SF3B2 SF3B2 FRA10AC1 FRA10AC1 DGCR14 DGCR14 IK IK CWC27 CWC27 THOC1 THOC1 ZNF830 ZNF830 SAP30BP SAP30BP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
DGCR14DiGeorge syndrome critical region gene 14; May be involved in pre-mRNA splicing (476 aa)
THOC1THO complex 1; Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5’ end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex [...] (657 aa)
MFAP1microfibrillar-associated protein 1; Component of the elastin-associated microfibrils (439 aa)
U2AF1U2 small nuclear RNA auxiliary factor 1; Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3’-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron (240 aa)
TTC14tetratricopeptide repeat domain 14 (770 aa)
SF3B2splicing factor 3b, subunit 2, 145kDa; Subunit of the splicing factor SF3B required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (895 aa)
TRIM41tripartite motif containing 41; Functions as an E3 ligase that catalyzes the ubiquitin- mediated degradation of protein kinase C (630 aa)
ZCCHC10zinc finger, CCHC domain containing 10 (170 aa)
SRA1steroid receptor RNA activator 1; Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand- dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis (236 aa)
UBCubiquitin C (685 aa)
ZNF830zinc finger protein 830; May act as a regulator of the cell cycle in embryos by participating in control of M phase (By similarity) (372 aa)
NKAPNFKB activating protein; Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter (415 aa)
FRA10AC1fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1 (315 aa)
CWC27CWC27 spliceosome-associated protein homolog (S. cerevisiae); PPIases accelerate the folding of proteins (By similarity) (472 aa)
PRPF40APRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae); Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing (930 aa)
IKIK cytokine, down-regulator of HLA II; May bind to chromatin (557 aa)
CCDC155coiled-coil domain containing 155; May be involved in meiotic chromosome dynamics and homolog pairing (By similarity) (562 aa)
CHERPcalcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation (916 aa)
SAP30BPSAP30 binding protein; Induces cell death. May act as a transcriptional corepressor of a gene related to cell survival. May be involved in the regulation of beta-2-microglobulin genes (308 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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