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PEBP1 PEBP1 MRPS2 MRPS2 PEBP4 PEBP4 MRPL23 MRPL23 MRPL22 MRPL22 MRPL13 MRPL13 MRPL33 MRPL33 RPL27A RPL27A MRPL16 MRPL16 MRPL15 MRPL15 MRPL17 MRPL17 MRPL49 MRPL49 RPL11 RPL11 MRPL43 MRPL43 MRPL1 MRPL1 MRPL19 MRPL19 MRPL46 MRPL46 MRPL27 MRPL27 MRPL47 MRPL47 DROSHA DROSHA MRPL36 MRPL36 MRPL32 MRPL32 MRPL40 MRPL40 MRPL41 MRPL41 MRPL34 MRPL34 DICER1 DICER1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
MRPL32mitochondrial ribosomal protein L32 (188 aa)
MRPL27mitochondrial ribosomal protein L27 (148 aa)
MRPS2mitochondrial ribosomal protein S2 (296 aa)
MRPL34mitochondrial ribosomal protein L34 (92 aa)
PEBP4phosphatidylethanolamine-binding protein 4; Seems to promote cellular resistance to TNF-induced apoptosis by inhibiting activation of the Raf-1/MEK/ERK pathway, JNK and phosphatidylethanolamine externalization (227 aa)
MRPL15mitochondrial ribosomal protein L15 (296 aa)
PEBP1phosphatidylethanolamine binding protein 1; Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (187 aa)
MRPL49mitochondrial ribosomal protein L49 (166 aa)
MRPL17mitochondrial ribosomal protein L17 (175 aa)
MRPL33mitochondrial ribosomal protein L33 (65 aa)
MRPL16mitochondrial ribosomal protein L16; Component of the large subunit of mitochondrial ribosome (251 aa)
MRPL13mitochondrial ribosomal protein L13 (178 aa)
MRPL46mitochondrial ribosomal protein L46 (279 aa)
MRPL1mitochondrial ribosomal protein L1 (325 aa)
MRPL40mitochondrial ribosomal protein L40 (206 aa)
MRPL43mitochondrial ribosomal protein L43 (235 aa)
DROSHAdrosha, ribonuclease type III; Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3’ and 5’ strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA- ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate matu [...] (1374 aa)
DICER1dicer 1, ribonuclease type III; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre- miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering [...] (1922 aa)
RPL27Aribosomal protein L27a (148 aa)
MRPL41mitochondrial ribosomal protein L41; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (137 aa)
RPL11ribosomal protein L11; Binds to 5S ribosomal RNA (By similarity). Required for rRNA maturation and formation of the 60S ribosomal subunits. Promotes nucleolar location of PML (By similarity) (178 aa)
MRPL23mitochondrial ribosomal protein L23 (153 aa)
MRPL36mitochondrial ribosomal protein L36; Component of the large subunit of the mitochondrial ribosome (Potential) (103 aa)
MRPL19mitochondrial ribosomal protein L19 (292 aa)
MRPL47mitochondrial ribosomal protein L47 (250 aa)
MRPL22mitochondrial ribosomal protein L22 (206 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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