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GRIN3A GRIN3A CNIH3 CNIH3 CNIH2 CNIH2 CACNG8 CACNG8 CACNG5 CACNG5 CACNG4 CACNG4 SHISA9 SHISA9 CACNG7 CACNG7 CACNG3 CACNG3 GRIN2D GRIN2D DLG4 DLG4 GRIN1 GRIN1 CAMK2G CAMK2G GRIN2B GRIN2B GRIN2A GRIN2A CALML5 CALML5 CAMK2A CAMK2A RASGRF1 RASGRF1 PLCG1 PLCG1 AKAP9 AKAP9 SPTAN1 SPTAN1 RASGRF2 RASGRF2 CALML6 CALML6 ACTN2 ACTN2 CALML3 CALML3
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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query proteins and first shell of interactors
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second shell of interactors
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Predicted Interactions
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CACNG3calcium channel, voltage-dependent, gamma subunit 3; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity) (315 aa)
CACNG7calcium channel, voltage-dependent, gamma subunit 7; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity only for GRIA1 and GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (275 aa)
PLCG1phospholipase C, gamma 1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (1291 aa)
CACNG4calcium channel, voltage-dependent, gamma subunit 4; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (327 aa)
GRIN2Dglutamate receptor, ionotropic, N-methyl D-aspartate 2D; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine (1336 aa)
RASGRF2Ras protein-specific guanine nucleotide-releasing factor 2; Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation (1237 aa)
CACNG8calcium channel, voltage-dependent, gamma subunit 8; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (425 aa)
CNIH3cornichon homolog 3 (Drosophila); Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization (160 aa)
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity) (1484 aa)
DLG4discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) (767 aa)
CACNG5calcium channel, voltage-dependent, gamma subunit 5; Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity) (275 aa)
CALML6calmodulin-like 6 (181 aa)
CNIH2cornichon homolog 2 (Drosophila); Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors (160 aa)
CALML3calmodulin-like 3; May be similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinities, to cellular substrates (149 aa)
CAMK2Gcalcium/calmodulin-dependent protein kinase II gamma (556 aa)
GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A; NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits (1464 aa)
AKAP9A kinase (PRKA) anchor protein (yotiao) 9 (3907 aa)
GRIN3Aglutamate receptor, ionotropic, N-methyl-D-aspartate 3A; NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity) (1115 aa)
ACTN2actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (894 aa)
GRIN1glutamate receptor, ionotropic, N-methyl D-aspartate 1 (943 aa)
SPTAN1spectrin, alpha, non-erythrocytic 1 (2477 aa)
CALML5calmodulin-like 5; Binds calcium. May be involved in terminal differentiation of keratinocytes (146 aa)
CAMK2Acalcium/calmodulin-dependent protein kinase II alpha; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity) (489 aa)
RASGRF1Ras protein-specific guanine nucleotide-releasing factor 1; Promotes the exchange of Ras-bound GDP by GTP (1273 aa)
SHISA9shisa homolog 9 (Xenopus laevis); Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity) (465 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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