node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CSTB | DPP7 | ENSP00000291568 | ENSP00000360635 | cystatin B (stefin B); This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B | dipeptidyl-peptidase 7; Plays an important role in the degradation of some oligopeptides | 0.538 |
CSTB | SARNP | ENSP00000291568 | ENSP00000337632 | cystatin B (stefin B); This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B | SAP domain containing ribonucleoprotein; Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single- stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis | 0.538 |
CSTB | UBC | ENSP00000291568 | ENSP00000344818 | cystatin B (stefin B); This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B | ubiquitin C | 0.788 |
DPP7 | CSTB | ENSP00000360635 | ENSP00000291568 | dipeptidyl-peptidase 7; Plays an important role in the degradation of some oligopeptides | cystatin B (stefin B); This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B | 0.538 |
DPP7 | MYCBP | ENSP00000360635 | ENSP00000380702 | dipeptidyl-peptidase 7; Plays an important role in the degradation of some oligopeptides | c-myc binding protein; May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC | 0.644 |
DPP7 | PLCG1 | ENSP00000360635 | ENSP00000244007 | dipeptidyl-peptidase 7; Plays an important role in the degradation of some oligopeptides | phospholipase C, gamma 1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration | 0.538 |
DPP7 | RIC8A | ENSP00000360635 | ENSP00000325941 | dipeptidyl-peptidase 7; Plays an important role in the degradation of some oligopeptides | resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) | 0.538 |
DPP7 | SARNP | ENSP00000360635 | ENSP00000337632 | dipeptidyl-peptidase 7; Plays an important role in the degradation of some oligopeptides | SAP domain containing ribonucleoprotein; Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single- stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis | 0.538 |
DPP7 | SELENBP1 | ENSP00000360635 | ENSP00000357861 | dipeptidyl-peptidase 7; Plays an important role in the degradation of some oligopeptides | selenium binding protein 1; Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity) | 0.644 |
DPP7 | UBC | ENSP00000360635 | ENSP00000344818 | dipeptidyl-peptidase 7; Plays an important role in the degradation of some oligopeptides | ubiquitin C | 0.802 |
DPP7 | WDR61 | ENSP00000360635 | ENSP00000267973 | dipeptidyl-peptidase 7; Plays an important role in the degradation of some oligopeptides | WD repeat domain 61; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and ’Ser-2’- and ’Ser-5’-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target gene [...] | 0.538 |
MYCBP | DPP7 | ENSP00000380702 | ENSP00000360635 | c-myc binding protein; May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC | dipeptidyl-peptidase 7; Plays an important role in the degradation of some oligopeptides | 0.644 |
MYCBP | UBC | ENSP00000380702 | ENSP00000344818 | c-myc binding protein; May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC | ubiquitin C | 0.795 |
PLCG1 | DPP7 | ENSP00000244007 | ENSP00000360635 | phospholipase C, gamma 1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration | dipeptidyl-peptidase 7; Plays an important role in the degradation of some oligopeptides | 0.538 |
PLCG1 | RIC8A | ENSP00000244007 | ENSP00000325941 | phospholipase C, gamma 1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration | resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) | 0.538 |
PLCG1 | SARNP | ENSP00000244007 | ENSP00000337632 | phospholipase C, gamma 1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration | SAP domain containing ribonucleoprotein; Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single- stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis | 0.538 |
PLCG1 | UBC | ENSP00000244007 | ENSP00000344818 | phospholipase C, gamma 1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration | ubiquitin C | 0.960 |
PLCG1 | WDR61 | ENSP00000244007 | ENSP00000267973 | phospholipase C, gamma 1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration | WD repeat domain 61; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and ’Ser-2’- and ’Ser-5’-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target gene [...] | 0.538 |
RIC8A | DPP7 | ENSP00000325941 | ENSP00000360635 | resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) | dipeptidyl-peptidase 7; Plays an important role in the degradation of some oligopeptides | 0.538 |
RIC8A | PLCG1 | ENSP00000325941 | ENSP00000244007 | resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) | phospholipase C, gamma 1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration | 0.538 |