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STRINGSTRING
GORASP1 GORASP1 COG3 COG3 SEC22A SEC22A SEC22C SEC22C BET1L BET1L TRAPPC1 TRAPPC1 TRAPPC8 TRAPPC8 GORASP2 GORASP2 USO1 USO1 BET3L BET3L BET1 BET1 TRAPPC5 TRAPPC5 SCFD1 SCFD1 STX5 STX5 TRAPPC3 TRAPPC3 RABL6 RABL6 SPINK7 SPINK7 YIPF5 YIPF5 YIPF7 YIPF7 RABIF RABIF YIF1B YIF1B TBC1D22B TBC1D22B YIF1A YIF1A RABGGTB RABGGTB RABAC1 RABAC1 TBC1D22A TBC1D22A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
RABAC1Rab acceptor 1 (prenylated); General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI (By similarity) (185 aa)
BET1blocked early in transport 1 homolog (S. cerevisiae); Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane (By similarity) (118 aa)
GORASP2golgi reassembly stacking protein 2, 55kDa; Plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after mitotic breakdown. May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (452 aa)
COG3component of oligomeric golgi complex 3; Involved in ER-Golgi transport (828 aa)
SEC22CSEC22 vesicle trafficking protein homolog C (S. cerevisiae); May be involved in vesicle transport between the ER and the Golgi complex (303 aa)
YIPF5Yip1 domain family, member 5; Plays a role in transport between endoplasmic reticulum and Golgi (257 aa)
SPINK7serine peptidase inhibitor, Kazal type 7 (putative); Probable serine protease inhibitor (85 aa)
TRAPPC8trafficking protein particle complex 8; May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (1435 aa)
STX5syntaxin 5; Mediates endoplasmic reticulum to Golgi transport (By similarity) (355 aa)
TRAPPC1trafficking protein particle complex 1; May play a role in vesicular transport from endoplasmic reticulum to Golgi (145 aa)
SEC22ASEC22 vesicle trafficking protein homolog A (S. cerevisiae); May be involved in vesicle transport between the ER and the Golgi complex (By similarity) (307 aa)
GORASP1golgi reassembly stacking protein 1, 65kDa; Stacking factor involved in the postmitotic assembly of Golgi stacks from mitotic Golgi fragments. Key structural protein required for the maintenance of the Golgi apparatus integrity- its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis. Also mediates, via its interaction with GM130, the docking of transport vesicles with the Golgi membranes (440 aa)
TRAPPC5trafficking protein particle complex 5; May play a role in vesicular transport from endoplasmic reticulum to Golgi (188 aa)
RABGGTBRab geranylgeranyltransferase, beta subunit; Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively (331 aa)
YIPF7Yip1 domain family, member 7 (280 aa)
TBC1D22ATBC1 domain family, member 22A (517 aa)
YIF1BYip1 interacting factor homolog B (S. cerevisiae) (314 aa)
RABIFRAB interacting factor; Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1 and RAB3A, but is less active on these proteins than on the SEC4 protein. Might play a general role in vesicular transport (123 aa)
BET3LBET3 like (S. cerevisiae); May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity) (181 aa)
RABL6RAB, member RAS oncogene family-like 6 (730 aa)
TRAPPC3trafficking protein particle complex 3; May play a role in vesicular transport from endoplasmic reticulum to Golgi (180 aa)
TBC1D22BTBC1 domain family, member 22B; May act as a GTPase-activating protein for Rab family protein(s) (By similarity) (505 aa)
YIF1AYip1 interacting factor homolog A (S. cerevisiae); Possible role in transport between endoplasmic reticulum and Golgi (293 aa)
BET1Lblocked early in transport 1 homolog (S. cerevisiae)-like; Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity) (111 aa)
SCFD1sec1 family domain containing 1; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity) (642 aa)
USO1USO1 vesicle docking protein homolog (yeast); General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity (By similarity) (971 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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