Your Input:
|
||||
GSC2 | goosecoid homeobox 2; May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC (205 aa) | |||
RHOXF1 | Rhox homeobox family, member 1; May be a transcription factor involved in reproductive processes (184 aa) | |||
ISL1 | ISL LIM homeobox 1; Binds and regulates the promoters of the insulin, glucagon and somatostatin genes. Involved in the specificarion of motor neurons in cooperation with LHX3 and LDB1 (By similarity) (349 aa) | |||
GSC | goosecoid homeobox; Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity) (257 aa) | |||
PRRX1 | paired related homeobox 1; Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity) (245 aa) | |||
RLIM | ring finger protein, LIM domain interacting; E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degr [...] (624 aa) | |||
LHX1 | LIM homeobox 1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (406 aa) | |||
LMO2 | LIM domain only 2 (rhombotin-like 1); Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state (227 aa) | |||
IFT172 | intraflagellar transport 172 homolog (Chlamydomonas); Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity) (1749 aa) | |||
LHX5 | LIM homeobox 5; Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system (402 aa) | |||
ISL2 | ISL LIM homeobox 2; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways (By similarity) (359 aa) | |||
LHX8 | LIM homeobox 8; Transcription factor involved in differentiation of certain neurons and mesenchymal cells (By similarity) (356 aa) | |||
LMX1A | LIM homeobox transcription factor 1, alpha; Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity) (382 aa) | |||
HESX1 | HESX homeobox 1; Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5’-AGCTTGAGTCTAATTGAATTAACTGTAC-3’. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity) (185 aa) | |||
OTP | orthopedia homeobox; Probably involved in the differentiation of hypothalamic neuroendocrine cells (325 aa) | |||
PROP1 | PROP paired-like homeobox 1; Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes (226 aa) | |||
ISX | intestine-specific homeobox; Transcription factor that regulates gene expression in intestine. May participate in vitamin A metabolism most likely by regulating BCMO1 expression in the intestine (By similarity) (245 aa) | |||
LMO3 | LIM domain only 3 (rhombotin-like 2) (145 aa) | |||
UNCX | UNC homeobox; Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions (By similarity) (531 aa) | |||
ALX1 | ALX homeobox 1; Transcriptional activator that acts at a palindromic recognition sequence to enhance the activity of the SV40 and TK promoters. Functions as a repressor with the prolactin promoter in vivo. May play a role in chondrocyte differentiation and may also influence cervix development (326 aa) | |||
ALX4 | ALX homeobox 4; Transcription factor involved in skull and limb development. Plays an essential role in craniofacial development, skin and hair follicle development (411 aa) | |||
LHX9 | LIM homeobox 9; Involved in gonadal development (By similarity) (397 aa) | |||
CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2; Transcriptional coactivator of the p300/CBP-mediated trancription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator- activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transacti [...] (270 aa) | |||
LHX3 | LIM homeobox 3; Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1 (402 aa) | |||
LHX2 | LIM homeobox 2; Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity) (406 aa) | |||
LDB1 | LIM domain binding 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Play a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity) (411 aa) |