26 items (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PDXP	pyridoxal (pyridoxine, vitamin B6) phosphatase; Protein serine phosphatase that dephosphorylates ’Ser-3’ in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho- tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5’-phosphate (PLP), pyridoxine 5’-phosphate (PMP) and pyridoxine 5’-phosphate (PNP), with [...] (296 aa)
	TGFB1	transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (390 aa)
	PROC	protein C (inactivator of coagulation factors Va and VIIIa); Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (461 aa)
	ELN	elastin (724 aa)
	DNAJC13	DnaJ (Hsp40) homolog, subfamily C, member 13 (2243 aa)
	FCN3	ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen); May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota (299 aa)
	CELA3A	chymotrypsin-like elastase family, member 3A; Efficient protease with alanine specificity but only little elastolytic activity (270 aa)
	FCN2	ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin); May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region (313 aa)
	PTX3	pentraxin 3, long; Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self- components and female fertility (By similarity) (381 aa)
	MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) (728 aa)
	PRSS12	protease, serine, 12 (neurotrypsin, motopsin); Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations (By similarity) (875 aa)
	C2	complement component 2 (752 aa)
	SUSD5	sushi domain containing 5 (629 aa)
	SEZ6L2	seizure related 6 homolog (mouse)-like 2; May contribute to specialized endoplasmic reticulum functions in neurons (By similarity) (910 aa)
	PGP	phosphoglycolate phosphatase (321 aa)
	CFD	complement factor D (adipsin); Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway (253 aa)
	RIPK4	receptor-interacting serine-threonine kinase 4; Involved in stratified epithelial development. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation (784 aa)
	FCN1	ficolin (collagen/fibrinogen domain containing) 1; Complement-activating lectin and pattern recognition receptor. Binds GlcNAc. Binds preferentially to 9-O-acetylated 2- 6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage (326 aa)
	PLAU	plasminogen activator, urokinase; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin (431 aa)
	MBL2	mannose-binding lectin (protein C) 2, soluble; Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA (248 aa)
	PTPRA	protein tyrosine phosphatase, receptor type, A (802 aa)
	ACAN	aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region (2530 aa)
	C4A	complement component 4A (Rodgers blood group) (1744 aa)
	ENSG00000244255	Complement factor B Ba fragment; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B (1266 aa)
	C4B	complement component 4B (Chido blood group) (1744 aa)
	CTRL	chymotrypsin-like (264 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAN	TGFB1	ENSP00000387356	ENSP00000221930	aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region	transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts	0.581
C2	CFD	ENSP00000299367	ENSP00000332139	complement component 2	complement factor D (adipsin); Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway	0.497
C2	MASP1	ENSP00000299367	ENSP00000296280	complement component 2	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.658
C2	TGFB1	ENSP00000299367	ENSP00000221930	complement component 2	transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts	0.427
C4A	CFD	ENSP00000396688	ENSP00000332139	complement component 4A (Rodgers blood group)	complement factor D (adipsin); Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway	0.506
C4A	MASP1	ENSP00000396688	ENSP00000296280	complement component 4A (Rodgers blood group)	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.553
C4B	CFD	ENSP00000415941	ENSP00000332139	complement component 4B (Chido blood group)	complement factor D (adipsin); Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway	0.548
C4B	FCN2	ENSP00000415941	ENSP00000291744	complement component 4B (Chido blood group)	ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin); May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region	0.560
C4B	MASP1	ENSP00000415941	ENSP00000296280	complement component 4B (Chido blood group)	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.934
C4B	PROC	ENSP00000415941	ENSP00000234071	complement component 4B (Chido blood group)	protein C (inactivator of coagulation factors Va and VIIIa); Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids	0.499
CELA3A	CTRL	ENSP00000290122	ENSP00000458537	chymotrypsin-like elastase family, member 3A; Efficient protease with alanine specificity but only little elastolytic activity	chymotrypsin-like	0.703
CFD	C2	ENSP00000332139	ENSP00000299367	complement factor D (adipsin); Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway	complement component 2	0.497
CFD	C4A	ENSP00000332139	ENSP00000396688	complement factor D (adipsin); Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway	complement component 4A (Rodgers blood group)	0.506
CFD	C4B	ENSP00000332139	ENSP00000415941	complement factor D (adipsin); Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway	complement component 4B (Chido blood group)	0.548
CFD	ENSG00000244255	ENSP00000332139	ENSP00000410815	complement factor D (adipsin); Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway	Complement factor B Ba fragment; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B	0.947
CFD	TGFB1	ENSP00000332139	ENSP00000221930	complement factor D (adipsin); Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway	transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts	0.910
CTRL	CELA3A	ENSP00000458537	ENSP00000290122	chymotrypsin-like	chymotrypsin-like elastase family, member 3A; Efficient protease with alanine specificity but only little elastolytic activity	0.703
ELN	FCN1	ENSP00000252034	ENSP00000360871	elastin	ficolin (collagen/fibrinogen domain containing) 1; Complement-activating lectin and pattern recognition receptor. Binds GlcNAc. Binds preferentially to 9-O-acetylated 2- 6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage	0.576
ENSG00000244255	CFD	ENSP00000410815	ENSP00000332139	Complement factor B Ba fragment; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B	complement factor D (adipsin); Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway	0.947
FCN1	ELN	ENSP00000360871	ENSP00000252034	ficolin (collagen/fibrinogen domain containing) 1; Complement-activating lectin and pattern recognition receptor. Binds GlcNAc. Binds preferentially to 9-O-acetylated 2- 6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage	elastin	0.576

page 1 of 3

Experiments

Cooccurrence

Databases

Neighborhood

Textmining

Fusion

Coexpression

© STRING Consortium 2017

Credits

Access

Info

About