node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACE | AGT | ENSP00000290866 | ENSP00000355627 | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | 0.999 |
ACE | AGTR2 | ENSP00000290866 | ENSP00000360973 | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety | angiotensin II receptor, type 2; Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation | 0.837 |
AGT | ACE | ENSP00000355627 | ENSP00000290866 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety | 0.999 |
AGT | AGTR2 | ENSP00000355627 | ENSP00000360973 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | angiotensin II receptor, type 2; Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation | 0.964 |
AGT | GNAI3 | ENSP00000355627 | ENSP00000358867 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor- regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division | 0.900 |
AGTR2 | ACE | ENSP00000360973 | ENSP00000290866 | angiotensin II receptor, type 2; Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety | 0.837 |
AGTR2 | AGT | ENSP00000360973 | ENSP00000355627 | angiotensin II receptor, type 2; Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | 0.964 |
AGTR2 | ERBB3 | ENSP00000360973 | ENSP00000267101 | angiotensin II receptor, type 2; Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); Binds and is activated by neuregulins and NTAK | 0.576 |
AGTR2 | GNAI2 | ENSP00000360973 | ENSP00000312999 | angiotensin II receptor, type 2; Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase- they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division | 0.592 |
AGTR2 | GNAI3 | ENSP00000360973 | ENSP00000358867 | angiotensin II receptor, type 2; Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor- regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division | 0.592 |
AGTR2 | MTUS1 | ENSP00000360973 | ENSP00000262102 | angiotensin II receptor, type 2; Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation | microtubule associated tumor suppressor 1 | 0.818 |
AGTR2 | PIK3CB | ENSP00000360973 | ENSP00000289153 | angiotensin II receptor, type 2; Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4- phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G- [...] | 0.576 |
AGTR2 | ZBTB16 | ENSP00000360973 | ENSP00000338157 | angiotensin II receptor, type 2; Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation | zinc finger and BTB domain containing 16; Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins | 0.639 |
CCDC88B | GNAI3 | ENSP00000349238 | ENSP00000358867 | coiled-coil domain containing 88B | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor- regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division | 0.501 |
CCDC88B | PIK3CB | ENSP00000349238 | ENSP00000289153 | coiled-coil domain containing 88B | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4- phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G- [...] | 0.403 |
ERBB3 | AGTR2 | ENSP00000267101 | ENSP00000360973 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); Binds and is activated by neuregulins and NTAK | angiotensin II receptor, type 2; Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation | 0.576 |
ERBB3 | PIK3CB | ENSP00000267101 | ENSP00000289153 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); Binds and is activated by neuregulins and NTAK | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4- phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G- [...] | 0.707 |
GNAI2 | AGTR2 | ENSP00000312999 | ENSP00000360973 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase- they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division | angiotensin II receptor, type 2; Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation | 0.592 |
GNAI2 | GNAI3 | ENSP00000312999 | ENSP00000358867 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase- they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor- regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division | 0.544 |
GNAI3 | AGT | ENSP00000358867 | ENSP00000355627 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor- regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | 0.900 |